TODAY STUDY GROUP GENETICS PROTOCOL

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 TODAY研究小组已经准备了一个方案，其主要目的是收集血液和表型信息，用于探索候选基因与2型糖尿病（T2 D）以及肥胖，胰岛素抵抗和胰岛素抵抗的心血管并发症之间的关系。 参与遗传学研究包括抽血分析糖尿病类型和DNA提取，以及收集基本家族史和病史。 从所有参与者获得适当的知情同意和同意，以提取DNA并将血液、遗传物质和病史发送到国立卫生研究院（NIH）的国立糖尿病、消化和肾脏疾病研究所（NIDDK）的中央储存库。 数据由中央存储库无限期保存。 NIDDK将在整个科学界发布征求建议书（RFP），以帮助开发新的诊断测试，新的治疗方法以及预防糖尿病和其他相关合并症的新方法。 I. 假设 这是DNA和临床信息的储存库。 希望访问该储存库的研究人员将向今日遗传学小组提交建议。 NIDDK计划发布一份RFA，征求针对改善糖尿病和相关并发症治疗和预防的研究的建议。 二. 具体目标 A. 为大约2,500名18岁之前被诊断患有2型糖尿病的人创建一个DNA和临床信息库。 此存储库将包含以下内容： a. 受试者的人口统计学信息和病史 B. 糖尿病家族史及糖尿病并发症、高血压、血脂异常、中风和心脏病发作。 C. 将测量随机葡萄糖和并行C肽，并收集DNA。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The TODAY study group has prepared a protocol with the primary objective of collecting blood and phenotypic information to be used to explore relationships between candidate genes and type 2 diabetes (T2D), as well as obesity, insulin resistance, and cardiovascular complications of insulin resistance. Participation in the genetics study includes a blood draw for analysis of diabetes type and DNA extraction, as well as collection of basic family and medical history. Appropriate informed consent and assent are obtained from all participants to extract DNA and send blood, genetic material, and medical history to the Central Repository of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). The data are kept indefinitely by the Central Repository. The NIDDK will issue requests for proposals (RFP) throughout the scientific community for research that may help in the development of new diagnostic tests, new treatments, and new ways to prevent diabetes and other related comorbidities. I. HYPOTHESIS This is a repository for DNA and clinical information. Investigators wishing to access the repository would submit proposals to the TODAY Genetics group. NIDDK plans to issue an RFA to solicit proposals that would target research leading to improvements in the treatment and prevention of diabetes and related complications. II. SPECIFIC AIMS A. Create a repository with DNA and clinical information for about 2,500 people diagnosed with type 2 diabetes before the age of 18. This repository will contain the following: a. Subject''s demographic information and medical history b. Family history of diabetes and complications of diabetes, hypertension, dyslipidemia, strokes and heart attacks. c. Random glucose and concurrent C-peptide will be measured and DNA will be collected.