The Center for Translational Genomic Phenotyping

描述(由申请人提供)：加州大学(UC)戴维斯翻译基因组表型鉴定中心(CTGP)：美国国家癌症研究所-人类癌症小鼠模型联盟(NCI-MMHCC)科学领先应用程序将为模型病理学的验证提供集中的发现驱动的体内和体外表型鉴定。这主要集中在癌症生物学上，但也影响到预防干预、实验治疗和癌症易感性计划。该应用程序分为五个部分。1.作为这项研究的总结，国际和平研究所罗伯特·卡迪夫博士是合作伙伴，也是过去和最近提交的几个MMHC研究项目的合作者。他是与刘易斯·乔多什、科里·阿巴特-申和罗伯特·施赖伯一起提交的“目标1”研究申请的联合L。他一直在MMHCC联盟内提供咨询和领导，涉及表型、将小鼠的病理结果转化为人类疾病，以及定义和公布对在癌症生物学、预防和实验治疗中使用小鼠模型至关重要的诊断、分期和分级标准。2.领导计划将A)以电子方式协调预防干预和癌症生物学等具体研究群组中NCI-MMCC内部的项目，并预期促进隶属于这些研究群组的U01获奖者之间的合作；B)促进整个MMCC以及与其他NCI网络和财团的合作，以划定研究资源或促进群组合作的试点项目；以及C)通过CAELMIR管理和加强现有的NCI癌症模型生物信息学基础设施，并将体内和体外图像准确地映射到协作中的相关人类生物信息学系统。3.沟通和协调将通过信息学工具实现，这些工具将把MMHC研究分支机构与基因组病理学学院收录的专家病理学/表型资源联系起来。这一群体组成了该国最主要的权威机构和最有经验的小鼠模型和比较病理学家。4.将通过专题讨论会和讲习班以及加州大学戴维斯分校戴维斯中心的开放访问实习生/访问教授方案实现外联。此外，加州大学戴维斯分校与Mutant Mouse区域资源中心的连接以及KnoKout Mouse项目库为鼠标建模社区提供了更多的服务。5.我们加州大学戴维斯分校的团队部分开发了MMHCC和NCI的临床前模型信息学。加州大学戴维斯分校已经开始研究，具体的试点项目设计需要从老鼠群体管理、病理实验室信息系统、整个幻灯片图像、放射图像数据和显示器以及使用caELMIR、camod和caBIG基础设施的电子“实验室笔记本”获得准确的集成数据。此应用程序与计划优先级唯一相关。这是一个以表型和病理学为中心的领导U01，得到了许多国家小鼠病理学专家的广泛支持，以及专为MMHCC联盟目的而设计的信息学发展的广泛背景和前期工作

DESCRIPTION (provided by applicant): The University of California (UC), Davis Center for Translational Genomic Phenotyping (CTGP): A National Cancer Institute-Mouse Models of Human Cancer Consortium (NCI-MMHCC) Science Leadership Application will provide centralized discovery-driven in-vivo and ex-vivo phenotyping for validation of model pathology. This is predominantly centered on Cancer Biology, but Impacts Preventative Interventions, Experimental Therapeutics and Cancer Susceptibility programs as well. The application is organized in five sections. 1. As a Summary of the Research, the PI, Dr. Robert Cardiff, is a Co-Pl, Co-I and collaborator on several past and newly submitted MMHCC research projects. He Is Co-l on "Goal 1" research applications submitted with Lewis Chodosh, Cory Abate-Shen, and Robert Schreiber. He has consistently provided consultation and leadership within the MMHCC Consortium with respect to phenotypes, translation of pathologic findings in the mouse to the human disease, and defining and publicizing criteria for diagnosis, staging and grading critical to the use of the mouse models in cancer biology, prevention, and experimental therapeutics. 2. The Leadership Plan will A) electronically coordinate intra-NCI-MMHCC projects in the specific research clusters of Preventative Interventions and Cancer Biology and anticipate fostering collaborations among the U0l awardees who are affiliated with these research clusters; B) foster collaborations throughout the MMHCC and with other NCI networks and consortia to delineate research resources or pilot projects that promote the cluster collaborations; and C) manage and enhance the existing NCI cancer model bioinformatics infrastructure through caELMIR with Integrated image archives of in-vivo and ex-vivo images that are accurately mapped to relevant human bioinformatics systems in collaboration. 3. The Communication and Coordination will be achieved through the informatics tools connecting the MMHCC research affiliates with the expert pathology/phenotyping resource embodied In the Academy for Genomic Pathology. This group constitutes most of the leading authorities and most experienced mouse model and comparative pathologists in the country. 4. Outreach will be achieved through symposia and workshops, as well as an open visiting trainee/ visiting professor program at the UC Davis center. In addition, the connections at UC Davis to the Mutant Mouse Regional Resource Center, and the Knockout Mouse Project Repository provide added outreach to the mouse modeling community. 5. Pre-Clinical Models Informatics for the MMHCC and the NCI has been developed, in part, by our group at UC Davis. Studies have been Initiated at UC Davis, and specific pilot projects designs demanding accurate integrated data from mouse colony management, pathology laboratory information systems, whole slide images, radiology image data and display and electronic "lab notebooks" using caELMIR, caMOD, and the caBIG infrastructure. This application is uniquely relevant to the program priorities. This is a Leadership U01 centered on phenotyping and pathology, with extensive support from a host of national experts In mouse pathology, and extensive background and preliminary work In development of Informatics uniquely designed to the purposes of the MMHCC consortium