WIHS Data Management and Analysis Center (WDMAC)

描述(改编自申请，第328页)：这项提议的目的是证明，在有效治疗的时代，与艾滋病毒感染妇女的自然史有关的关键假设可以通过继续跟踪参加妇女机构间艾滋病毒研究(WIHS)的个人来最好地得到解决。WIHS成立于1993年，目的是研究美国女性中的艾滋病毒疾病，它已经建立了一个经验丰富的研究网络和广泛的基础设施，作为尖端实验室和临床科学的平台。参与者包括传统上研究不足的人群，但WIHS制定了有效的战略，成功地保持保留和后续行动，从而确保他们的长期特征和结果的确定。为了利用在定期访问中收集的全面数据，已经实施了最先进的分析方法，以评估在治疗开始之前和之后收集的因素与广泛的有益和不利结果的关联。除了作为WIHS核心研究的一部分测试重要假设外，我们还创建了一个数据和样本的研究平台，构成了当前和未来研究的重要工具。这个平台允许WIHS社区内外的研究人员使用纵向收集的数据和样本来测试新的假设，从而避免了重新编制所需资源的成本。这项研究具有高度的协作性，通过研究员发起的研究(R01和其他机制)与众多研究人员共享数据和标本，并通过WIHS关联的早期职业发展奖支持新的临床科学家。这些要素中的每一个都有助于持续提高生产率，截至本报告提交时，已有约320种出版物。WIHS的科学和业务部分是复杂和动态的。本申请的A部分将介绍我们自2002年3月提交上一份申请以来取得的队列和关键科学成就；介绍我们的科学和组织结构；以及我们提出的科学假设和2007-2012年研究议程，该议程已被组织成四个相互关联的研究项目和六个核心。

DESCRIPTION (adapted from application, page 328): The purpose of this proposal is to demonstrate that key hypotheses related to the natural history of HIV-infected women in the era of potent therapy can be best addressed through continued follow up of individuals enrolled in the Women's Interagency HIV Study (WIHS). Established in 1993 to study HIV disease among women in the U.S., the WIHS has assembled an experienced research network and an extensive infrastructure that serves as a platform for cutting-edge laboratory and clinical science. Participants encompass a traditionally understudied population, yet WIHS has developed effective strategies to successfully maintain retention and follow up, thus ensuring their long-term characterization and the ascertainment of outcomes. To capitalize upon the comprehensive data collected at regularly scheduled visits, state-of-the art analytical approaches have been implemented to assess the association of factors collected prior to and after therapy initiation with a broad spectrum of beneficial and adverse outcomes. In addition to testing important hypotheses as part of the core WIHS study, we have created a research platform of data and specimens that constitutes an important tool for current and future studies. This platform permits investigators inside and outside the WIHS community to use longitudinally collected data and specimens to test new hypotheses, and thus avoid the costs of compiling needed resource de novo. The study has been highly collaborative, sharing data and specimens with a multitude of investigators funded through investigator-initiated studies (R01s and other mechanisms) and in supporting new clinical scientists via WIHS linked early career development awards. Each of these elements has contributed to continued productivity, with some 320 publications as of this submission. The scientific and operational components of the WIHS are complex and dynamic. Part A of this application will describe the cohort and key scientific achievements that have occurred since our previous submission in March 2002; a presentation of our scientific and organizational structure; and our proposed scientific hypotheses and a research agenda for 2007-2012 that has been organized into four interrelated research projects and six cores.