THYMIC NURSE CELL ENVIRONMENT IN PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 TNC微环境在系统性红斑狼疮发病中的作用 胸腺护士细胞（TNC）在MHC限制和凋亡胸腺细胞的去除中具有主要作用。随着系统性红斑狼疮（SLE）的发病和进展，TNCs严重耗竭。本研究的主要目的是确定狼疮小鼠胸腺中TNCs的替代是否会减少或消除疾病症状。 在这些研究中，发现胸腺滋养细胞表达细胞角蛋白5和8（K5和K8）以及转录因子63（Trp-63）。Trp-63的表达是上皮细胞祖细胞的特征。这表明，跨国公司可能有潜力重新填充上皮细胞的胸腺特征的狼疮易感小鼠的无区。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The TNC Microenvironment in the Development of Systemic Lupus Erythematosus. Thymic Nurse Cells (TNCs) have a major role in MHC restriction and the removal of apoptotic thymocytes. TNCs are severely depleted with disease onset and progression in systemic lupus erythematosus (SLE). The major goal of this study is to determine if the replacement of TNCs in the thymus of lupus mice will reduce or eliminate disease symptoms. In these studies thymic nurse cells were found to express the cytokeratins five and eight (K5 and K8) as well as the transcription factor 63 (Trp-63). The expression of Trp-63 is a characteristic of epithelial cell progenitors. This suggests that TNCs may have the potential to repopulate epithelial-free zones characteristic of the thymi of lupus-prone mice.