STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL

该合同的目的是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。该合同涉及通过灌胃和皮肤途径对五种化学品进行慢性前和慢性研究，包括五溴二苯醚（DE-71）、吲哚-3-甲醇、甲基苯乙烯基酮、三丙烯酸戊酯和三羟甲基丙烷三丙烯酸酯。五溴二苯醚三丙烯酸酯、五溴二苯醚和吲哚-3-甲醇的90天研究已经完成并报告。本合同取消了三丙烯酸戊酯和吲哚-3甲醇的2年研究。2年甲基苯乙烯基酮和三羟甲基丙烷三丙烯酸酯研究的活体部分已经完成。目前正在对大鼠和小鼠进行为期两年的五溴二苯醚长期研究。在对大鼠进行的五溴二苯醚慢性研究中，大鼠从妊娠第6天开始在子宫内接受治疗，一直持续到哺乳期，并将从青春期持续到成年期。给药将持续至大鼠2岁，此时将彻底检查动物是否存在致癌性体征。 关键词致癌性;毒性; Wistar Han大鼠; Fisher大鼠; B6 C3 F1小鼠;围产期;三丙烯酸酯、阻燃剂;五溴二苯醚; DE-71;吲哚-3-甲醇;甲基苯乙烯基酮;三丙烯酸戊酯;和三羟甲基丙烷三丙烯酸酯。

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This contract involes the prechronic and chronic studies of 5 chemicals by gavage and dermal routes including Pentabromodiphenyl oxide (DE-71); Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate. The 90-Day studies of Pentaerythritol triacrylate, Pentabromodiphenyl oxide and Indole-3-carbinol have been completed and reported. The 2-year studies for Pentaerythritol triacrylate and Indole-3 carbinol have been cancelled from this contract. The in-life portion of the 2-year Methyl styryl ketone and Trimethylolpropane triacrylate studies have been completed. Chronic 2 year studies on Pentabromodiphenyl oxide are ongoing in rats and mice. In the Pentabromodiphenyl oxide chronic rat study, rats have been treated in utero beginning on gestation day 6, continuing through the lactation period and will be continuously treated through puberty to adulthood. Dosing will continue until rats are two years of age at which time animals will be thoroughly examined for signs of carcinogenicity. Keywords Carcinogenicty; Toxicity; Wistar Han rats; Fisher rats; B6C3F1 mice; perinatal; triacrylates, flame retardants; Pentabromodiphenyl oxide; DE-71; Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate.