TYPE I DIABETES GENETIC CONSORTIUM (NORTH AMERICAN REGIONAL NETWORK)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 1型糖尿病遗传学联合会(T1DGC)将组织国际努力，以确定决定S患1型糖尿病风险的基因。在世界范围内，由于缺乏足够的临床和遗传资源，实现这一目标的进展受到限制。寻求建立来自多个种族群体的具有良好特征的家庭的资源库，以促进基于统计动力的全基因组连锁研究的1型糖尿病基因的定位和表征。我们想让德克萨斯儿童S医院作为北美网络的招募中心之一。目前，美国有47个中心参与了这项国际努力，旨在确定与1型糖尿病相关的基因。 1型糖尿病遗传学联合会的科学目标是： 1.确定、研究和建立3000个受影响的兄弟姐妹(ASP)家庭的DNA来源，这些家庭至少有两个1型糖尿病兄弟姐妹，+/-他们的父母，以及+/-最多两个非糖尿病兄弟姐妹，用于研究可能与1型糖尿病相关的基因； 2.确定、研究和确定5000个三人家庭的DNA可再生来源，这些家庭有一个1型糖尿病儿童及其父母，如果亲生父母自我认同为非裔美国人或墨西哥裔美国人。 3.确定、研究和建立1800名自认为非裔美国人和/或墨西哥裔美国人、900名(对照)1型糖尿病患者和900名非(病例)1型糖尿病患者的可再生DNA来源。 4.为科学界创建一个数据库，以促进对1型糖尿病易感基因的搜索； 5.提供中央DNA储存库，以便对1型糖尿病的遗传结构和功能进行有针对性的研究； 6.评估扩大研究成果的机会，以开发1型糖尿病领域的风险预测、预防和治疗方法。 7.为了实现这些目标，T1DGC将从世界各地五个研究确定的地理区域--亚太地区、欧洲、拉丁美洲、北美和联合王国--收集兄弟姐妹和三人家庭的信息和血液样本。北美网络还将招募自我认同为非裔美国人和/或墨西哥裔美国人、患有1型糖尿病但没有1型糖尿病的个人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individual s risk for type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is sought that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. We would like to enroll Texas children s Hospital as one of the centers for recruitment in the North American Network. Currently, there are 47 centers in the U.S. participating in this international effort, aiming to characterize genes related to Type 1 diabetes. The scientific objectives of the Type 1 Diabetes Genetics Consortium are: 1. To ascertain, study and establish a renewable source of DNA on 3000 affected sib-pair (ASP) families with at least two type 1 diabetic siblings, +/- their parents, and +/- up to two non-diabetic siblings for studies to map genes that may be associated with type 1 diabetes; 2. To ascertain, study and establish a renewable source of DNA on 5000 trio families with one type 1 diabetic child and both their parents, if the biological parents self -identify as African American or Mexican American . 3. To ascertain, study and establish a renewable source of DNA on 1800 individuals self-identifying as African American and or/ Mexican American, 900 with (control) type 1 diabetes and 900 without (case) type 1 diabetes. 4. To create a database for the scientific community that would facilitate the search for type 1 diabetes susceptibility genes; 5. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; 6. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of type 1 diabetes. 7. To meet these objectives, the T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. The North American Network will also be recruiting individuals self-identifying as African American and or/ Mexican American, with type 1 diabetes and without type 1 diabetes.