TYPE I DIABETES GENETIC CONSORTIUM (NORTH AMERICAN REGIONAL NETWORK)

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 1型糖尿病遗传学联盟（T1 DGC）将组织国际努力，以确定决定1型糖尿病个体风险的基因。由于缺乏足够的临床和遗传资源，世界范围内实现这一目标的进展受到限制。创建一个资源库的良好特征的家庭，从多个种族群体的目的，将有利于本地化和1型糖尿病基因的特征的基础上，统计动力全基因组连锁研究。我们希望将德克萨斯儿童医院作为北美网络的招聘中心之一。目前，美国有47个中心参与了这项国际努力，旨在表征与1型糖尿病相关的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individuals risk for type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is sought that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. We would like to enroll Texas childrens Hospital as one of the centers for recruitment in the North American Network. Currently, there are 47 centers in the U.S. participating in this international effort, aiming to characterize genes related to Type 1 diabetes.