TYPE I DIABETES GENETIC CONSORTIUM (NORTH AMERICAN REGIONAL NETWORK)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摘要 1型糖尿病遗传联盟(T1DGC)将组织国际努力，以确定决定个人患1型糖尿病风险的基因。在世界范围内，由于缺乏足够的临床和遗传资源，实现这一目标的进展受到限制。寻求建立来自多个种族群体的具有良好特征的家庭的资源库，以促进基于统计动力的全基因组连锁研究的1型糖尿病基因的定位和表征。我们想让德克萨斯儿童医院成为北美网络的招募中心之一。目前，美国有47个中心参与了这项国际努力，旨在确定与1型糖尿病相关的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individuals risk for type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is sought that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. We would like to enroll Texas childrens Hospital as one of the centers for recruitment in the North American Network. Currently, there are 47 centers in the U.S. participating in this international effort, aiming to characterize genes related to Type 1 diabetes.