TYPE I DIABETES GENETIC CONSORTIUM (NORTH AMERICAN REGIONAL NETWORK)

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 摘要 1 型糖尿病遗传学联盟 (T1DGC) 将组织国际努力来识别决定个人患 1 型糖尿病风险的基因。在世界范围内，由于缺乏足够的临床和遗传资源，实现这一目标的进展受到限制。寻求创建来自多个种族群体的特征良好的家庭资源库，这将有助于基于统计支持的全基因组连锁研究对 1 型糖尿病基因进行定位和表征。我们希望将德克萨斯儿童医院纳入北美网络招募中心之一。目前，美国有 47 个中心参与这项国际努力，旨在鉴定与 1 型糖尿病相关的基因特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individuals risk for type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is sought that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. We would like to enroll Texas childrens Hospital as one of the centers for recruitment in the North American Network. Currently, there are 47 centers in the U.S. participating in this international effort, aiming to characterize genes related to Type 1 diabetes.