TODAY STUDY GROUP GENETICS PROTOCOL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 今天的研究小组已经准备了一个方案，主要目的是收集血液和表型信息，用于探索候选基因与2型糖尿病(T2D)以及肥胖、胰岛素抵抗和胰岛素抵抗的心血管并发症之间的关系。参与遗传学研究包括抽血分析糖尿病类型和提取DNA，以及收集基本家族史和病史。从所有参与者那里获得适当的知情同意和同意，以提取DNA，并将血液、遗传物质和病史发送到国家卫生研究院(NIH)国家糖尿病、消化和肾脏疾病研究所(NIDDK)的中央储存库。数据由中央存储库无限期保存。 NIDDK将在整个科学界发布征求建议书(RFP)，以进行可能有助于开发新的诊断测试、新的治疗方法和新的方法来预防糖尿病和其他相关并发症的研究。 这是DNA和临床信息的储存库。希望访问该存储库的调查人员将向今日遗传学小组提交建议。NIDDK计划发布RFA以征求建议，这些建议将针对导致改善糖尿病及相关并发症治疗和预防的研究。 答：为大约2500名18岁之前被诊断为2型糖尿病的人创建一个包含DNA和临床信息的存储库。该存储库将包含以下内容： A.受试者S的人口统计信息和病史 糖尿病家族史及糖尿病、高血压、血脂异常、中风和心脏病发作的并发症。 C.将测量随机血糖和并发的C肽，并收集DNA。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The TODAY study group has prepared a protocol with the primary objective of collecting blood and phenotypic information to be used to explore relationships between candidate genes and type 2 diabetes (T2D), as well as obesity, insulin resistance, and cardiovascular complications of insulin resistance. Participation in the genetics study includes a blood draw for analysis of diabetes type and DNA extraction, as well as collection of basic family and medical history. Appropriate informed consent and assent are obtained from all participants to extract DNA and send blood, genetic material, and medical history to the Central Repository of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). The data are kept indefinitely by the Central Repository. The NIDDK will issue requests for proposals (RFP) throughout the scientific community for research that may help in the development of new diagnostic tests, new treatments, and new ways to prevent diabetes and other related comorbidities. This is a repository for DNA and clinical information. Investigators wishing to access the repository would submit proposals to the TODAY Genetics group. NIDDK plans to issue an RFA to solicit proposals that would target research leading to improvements in the treatment and prevention of diabetes and related complications. A. Create a repository with DNA and clinical information for about 2,500 people diagnosed with type 2 diabetes before the age of 18. This repository will contain the following: a. Subject''s demographic information and medical history b. Family history of diabetes and complications of diabetes, hypertension, dyslipidemia, strokes and heart attacks. c. Random glucose and concurrent C-peptide will be measured and DNA will be collected.