A PHASE II STUDY OF 3'-DEOXY-3'-18F FLUOROTHYMIDINE (FLT) IN INVASIVE BREAST

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案旨在评估局部晚期乳腺癌患者原发肿瘤的[18F]Flt摄取参数与化疗完全反应之间的关系。 该议定书的目标包括： 评价[18F]Flt摄取参数与临床解剖(CT)和代谢(FDG PET摄取)反应的关系 比较[18F]Flt和[18F]FDG摄取参数在预测局部晚期乳腺癌患者早期治疗反应(治疗完成前的反应评估)中的作用。 乳腺癌[18F]Flt摄取参数与肿瘤增殖标记物的相关性研究 继续监测潜在的安全问题并确定与[18F]氟胸腺苷(Flt)给药相关的任何生理效应

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is designed to evaluate the relationship between [18F]FLT uptake parameters and pathologic complete response to chemotherapy of the primary tumor in patients with locally advanced breast cancer. The protocol aims include: To evaluate the relationship between [18F]FLT uptake parameters and the clinical anatomical (CT) and metabolic (FDG PET uptake) response To compare the utility of [18F]FLT and [18F]FDG uptake parameters for predicting early treatment response (response assessment prior to completion of therapy) in patients with locally advanced breast cancer. To demonstrate correlation between [18F]FLT uptake parameters and tumor proliferation markers in breast cancer To continue to monitor for potential safety issues and define any physiologic effects associated with [18F] fluorothymidine (FLT) administration