MULTI-CENTER TRIAL TO EVALUATE HOME-BASED ASSESSMENT METHODS FOR ALZHEIMER DISEA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对有效、高效和经济的方法进行临床试验以预防阿尔茨海默病S病的需求尚未得到满足。传统的面对面就诊既耗时又昂贵，可能会将某些人排除在外，例如年龄较大、行动不便或患有重大疾病的人。这些人可能是认知能力下降的最大风险人群，也可能是那些没有经济资源前往研究地点的人。预防试验还需要很长的观察期，这些同样的卫生、资源和交通问题可能会导致显著的退出。这些障碍增加了临床试验的费用，因为它们需要大样本量、昂贵的临床工作人员和长时间的观察期。因此，以家庭为基础的评估可能会导致更具代表性的招聘那些最有可能下降的人，更好地保留和降低学习成本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an unmet need for effective, efficient and economical methods for conducting clinical trials to prevent Alzheimer s disease. Traditional in-person visits to a clinic are time consuming and costly and may exclude certain individuals from participation, such as those who are older, or are less mobile or who have significant medical illnesses. These may be the very people who are at greatest risk for cognitive decline, as well as those without financial resources for transportation to a study site. Prevention trials also require long observation periods and these same issues of health, resources, and transportation may cause significant drop out. These obstacles increase expense of clinical trials as they require large sample sizes, costly clinical staff and long observation periods. Thus, home-based assessments may lead to more representative recruitment of those most at risk for decline, better retention and reduced study costs.