RANDOMIZED, DOUBLE-BLIND TRIAL OF CLINDAMYCIN, TRIMETHOPRIM-SULFAMETHOXAZOLE, OR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 金黄色葡萄球菌（Staph）是一种可导致皮肤感染和其他严重和致命感染的细菌。社区相关耐甲氧西林金黄色葡萄球菌（CA-MRSA）是对许多抗生素具有耐药性的葡萄球菌感染类型。CA-MRSA感染突然变得非常普遍，而10年前他们闻所未闻。CA-MRSA对许多抗生素都有抗药性，因此医生不确定哪种抗生素对皮肤感染最有效，而皮肤感染现在主要是由CA-MRSA引起的。 了解如何最好地治疗皮肤感染，特别是那些所谓的？简单的皮肤和软组织感染（USSTI），我们需要做一个临床试验来比较专家认为最好的抗生素。然而，没有证据表明这些抗生素有多好（有效）或安全。 我们将在CA-MRSA常见地区的儿童和成人中进行uSSTI治疗的临床试验-特别是治疗脓肿（疖子）和/或蜂窝织炎（温和的皮肤感染）。 本研究的主要目的是比较两种抗生素，克林霉素和甲氧苄啶-磺胺甲恶唑（TMP-SMX）治疗uSSTI的治愈率。治疗将结合治疗脓肿的标准护理进行，即切开引流（即，兰辛疖子）。有初步资料表明，对于小脓肿患者，仅切开引流而不使用抗生素可能就足够了。因此，将有小病灶的受试者随机分配接受克林霉素、TMP-SMX或安慰剂治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Staphylococcus aureus (Staph) is a germ that can cause skin infections and other serious and deadly infections. Community-Associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are types of Staph infections that are resistant to many antibiotics. CA-MRSA infections are suddenly very common, whereas 10 years ago they were unheard of. CA-MRSA are resistant to many antibiotics so doctors are not sure which antibiotics work best against skin infections, which are now caused mostly by CA-MRSA. To understand how to best treat skin infections, specifically ones called ?uncomplicated skin and soft tissue infections? (uSSTIs), we need to do a clinical trial to compare antibiotics that experts think are best. However, there is no proof about how good (efficacious) or safe these antibiotics are. We will perform a clinical trial of treatment of uSSTIs --specifically treatment of abscesses (boils) and/or cellulitis (bland skin infection)--in both children and adults in areas where CA-MRSA is common. The primary objective of this study is to compare the cure rates of two antibiotics, clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of uSSTIs. Treatment will be done in conjunction with the standard of care for treatment of abscesses, which is incision and drainage (i.e., lancing a boil). There is preliminary information that incision and drainage alone without antibiotics may be sufficient for patients with small abscesses. Therefore, subjects with small abscesses will be randomized to be treated with either clindamycin, TMP-SMX, or placebo.