STUDY TO DETERMINE HOW COMMUNITY ASSOCIATED MRSA SURVIVES ON HUMAN SKIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去10年中，MRSA感染已成为一种大流行，但MRSA大流行的分子基础仍不清楚。本研究的目的是确定新获得的CA-MRSA的ACME基因元件是否是直接导致人类皮肤定植增强的因素。在这项初步研究中，我们将确定5-20名健康的成年人，他们以前在皮肤或鼻子上殖民了MRSA USA300。每个受试者都将接种自己的MRSA分离株，以确定MRSA在皮肤上存活的最佳接种量和安全参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infection with MRSA has become a pandemic over the past 10 years, but the molecular basis for the MRSA pandemic remains unknown. The purpose of this study is to determine whether the newly acquired ACME genetic element of CA-MRSA is the factor directly responsible for enhanced human skin colonization. In this pilot study we will identify 5-20 healthy adults previously colonized with MRSA USA300 on their skin or nose. Each subject will be inoculated with their own MRSA isolate, in order to identify the optimal inoculum and safety parameters for MRSA survival on the skin.