P7: VEHICLES TO IMPROVE NOSE TO BRAIN BIOAVAILABILITY OF DRUGS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 探索壳聚糖作为屏障调节剂用于递送治疗剂特别是BDNF和左旋多巴的用途。 具体目的1：研究壳聚糖对不同分子量标记物透过嗅粘膜的影响。 目的二：研究壳聚糖对BDNF和左旋多巴经嗅粘膜渗透的影响。 具体目的3：研究壳聚糖对大鼠脑源性神经营养因子（BDNF）和左旋多巴（Levodopa）鼻-脑生物利用度的影响。 具体目标4：制备药物-聚合物共胶束系统，并研究其在存在和不存在壳聚糖的情况下穿过嗅粘膜的渗透性，并研究治疗药物的脑生物利用度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Explore the use of chitosan as the barrier modulating agent for the delivery of therapeutic agents specifically, BDNF and levodopa. Specific Aim 1: To investigate the effect of chitosan on the permeation of markers of different molecular weight across olfactory mucosa. Specific Aim 2: To study the effect of chitosan on the permeation of BDNF and levodopa across the olfactory mucosa. Specific Aim 3: To study the effect of chitosan on nose to brain bioavailability of BDNF and Levodopa in rat model. Specific Aim 4: To prepare drug-polymer co-micelle systems and to investigate their permeability across the olfactory mucosa in presence and absence of chitosan and to study the brain bioavailability of therapeutic agents.