GENETICS OF EARLY LUPUS AUTOIMMUNITY IN AFRICAN AMERICANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的主要目标将是确定在临床疾病发展之前发生的自身抗体形成的遗传决定因素。第一阶段将确定已进行基因分型的样本中的自身抗体图谱。第二阶段将在第二组样本中复制这些发现，对抗体图谱和特定基因座的基因进行分型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project will be to identify the genetic determinants of autoantibody formation what occurs before the development of clinical disease. The first phase will be to determine the autoantibody profile in samples that have already been genotyped. The second phase will be to replicate these findings in a second set of samples typed for both antibody profile and genotype at specific loci.