GENES FOR EARLY SYSTEMIC LUPUS ERYTHEMATOSUS AUTOIMMUNITY

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 该项目的主要目标是确定在临床疾病发展之前发生的自身抗体形成的遗传决定因素。第一阶段将是确定已进行基因分型的样本中的自身抗体谱。第二阶段将在第二组样本中复制这些发现，这些样本在特定位点上进行抗体谱和基因型分型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary objective of this project will be to identify the genetic determinants of autoantibody formation what occurs before the development of clinical disease. The first phase will be to determine the autoantibody profile in samples that have already been genotyped. The second phase will be to replicate these findings in a second set of samples typed for both antibody profile and genotype at specific loci.