Loyola Alcohol Research Center (LARC)

描述（由申请人提供）：本P30补助金申请的总体目标是1）支持新的教师招聘，以加强通过生物医学研究核心中心的NIH补助金研究资源和2）建立洛约拉的酒精研究中心（LARC）。我们预计，获得这一P30补助金将使我们能够更好地指导我们的酒精研究兴趣的方向酒精和伤害，并使我们成为在未来的P30酒精研究中心补助金申请更具竞争力。在LARC的研究的主题源于正在进行的工作在博士的实验室伊丽莎白·J·科瓦奇和洛约拉的更广泛的酒精研究计划（阿普）的成员，谁继续工作重叠，但独立的研究，旨在确定的机制，通过酗酒暴露增加组织损伤后受伤或感染，并阻碍随后的修复过程。在美国，近50%的成年烧伤和创伤患者在受伤前饮酒，他们的受伤严重到需要住院治疗。最近的证据表明，这些受试者中的绝大多数不是依赖性饮酒者，而是在急性或狂欢的基础上饮酒。因此，进行研究，检查单次或多次酗酒事件的影响，其次是伤害是临床相关的和重要的。与P30机制的目标一致，Kovacs博士和同事计划招募一位新的终身助理教授，他们有共同的兴趣加入这个活跃的多学科研究和培训小组，专注于酒精和组织损伤。科瓦奇博士和一批精选的教师将担任实习生的高级和同行导师。她和导师们将帮助新成员建立自己的独立研究计划，并促进她融入小组项目，从而加快中心的研究计划。加入一个互动的研究团队将加快新教师的进步，并让他/她的知识和技能，这一临床相关的问题 公共卫生相关性：这个P30补助金申请的总体目标是支持新的教师招聘，以促进酒精和组织损伤/修复的研究。近一半需要住院治疗的成年烧伤和创伤患者在受伤前饮酒。来自我们小组和其他人的证据表明，受伤前饮酒会增加组织损伤，并阻碍随后的修复过程。

DESCRIPTION (provided by applicant): The overall goals of this P30 grant application are to 1) support New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers for NIH grant and 2) establish the Loyola's Alcohol Research Center (LARC). We anticipate that obtaining this P30 grant will enable us to better direct our alcohol research interests in the direction of alcohol and injury and allow us to become more competitive in a future P30 Alcohol Research Center grant application. The theme of the research at LARC stems from ongoing work in the laboratory of Dr. Elizabeth J. Kovacs and members of Loyola's broader Alcohol Research Program (ARP), who continue to work on overlapping but independent studies designed to determine the mechanisms by which binge alcohol exposure increases tissue damage after an injury or infection and impedes the subsequent repair process. In the United States, nearly 50% of the adult burn and trauma patients who sustain injuries severe enough to require hospitalization consumed alcohol prior to their injuries. Recent evidence reveals that the vast majority of these subjects are not dependent drinkers, but rather consume alcohol on an acute or binge basis. Thus, performing studies that examine the effects of single or multiple binge drinking episodes followed by injury is both clinically relevant and significant. Consistent with goals of the P30 mechanism, Dr. Kovacs and colleagues plan to recruit a new tenure-track assistant professor with common interests to join this active, multi-disciplinary research and training group focusing on alcohol and tissue injury. Dr. Kovacs and a select group of faculty will serve as senior and peer mentors for the trainee. She and the mentors will help the new recruit to establish her own independent research program and facilitate her integration into to group projects that will lead toward acceleration of the research initiatives of the Center. Joining an interactive research team will accelerate the progress of the new faculty member and allow him/her knowledge and skills to this clinically relevant problem PUBLIC HEALTH RELEVANCE: The overall goal of this P30 grant application is to support new faculty recruitment to facilitate research in alcohol and tissue injury/repair. Nearly half of the adult burn and trauma patients who require hospitalization consumed alcohol prior to their injuries. Evidence from our group and others reveals that consuming alcohol prior to injury increases tissue damage and impedes the subsequent repair process.