Molecular Virology Core

芯 核心D分子病毒学核心由HIV/AIDS DNA序列分析组件、BSL-3病毒学设施和microRNA功能/RNA干扰技术组成，以满足杜克大学基础和临床转化HIV及相关机会性感染研究不断发展的需求。的 分子病毒学核心的具体目标是： 1.提供核心服务，以促进DNA测序、分子病毒学分析的实施，并通过共享资源以具有成本效益的方式为CFAR实验室的RNA干扰和microRNA功能分析提供最先进的支持。 2.提供与特定人类基因在HIV-1、机会性感染或艾滋病相关恶性肿瘤的复制和发病机制中的作用有关的专业知识和核心资源。 3.促进学术界和工业界之间的跨学科合作，以进一步改进核心提供的技术，并提供一个可以促进合作的坚实资源。 4.为CFAR科学家提供现有和新开发的病毒学方法的教育和培训机会。 为了实现这些目标，分子病毒学核心是A）致力于通过多个QA/QC程序保持高质量的试剂和数据，以及B）建立基于CFAR研究者当前和未来科学需求的病毒学资源。

CoreD Core D Molecular Virology Core is comprised of an HIV/AIDS DNA sequence analysis component, a BSL-3 virology facility, and microRNA function/RNA interference technologies to serve the evolving needs of basic and clinical translational HIV and associated opportunistic infections research at Duke University. The specific aims of the Molecular Virology Core are: 1. Provision of Core Services to facilitate the implementation of DNA sequencing, molecular virology assays, and state-of-the-art support for RNA interference and microRNA functional analyses in CFAR laboratories through shared resources in a cost efficient manner. 2. To provide expertise and core resources related to the role of specific human genes in the replication and pathogenesis of HIV-1, opportunistic infections or AIDS-associated malignancies. 3. To stimulate interdisciplinary collaborations between academia and industry to further improve the technology offered by the Core and to provide a solid resource on which collaborations can be fostered. 4. To provide education and training opportunities to CFAR scientists in existing and newly developed virologic methodologies. In order to achieve these aims, the Molecular Virology Core is A) committed to maintaining a high quality of reagents and data through multiple QA/QC procedures and B) establishing a virologic resource that is based on current and future scientific needs of CFAR investigators.