IMPAIRED REGULATION OF CYTOCHROMES P450 DURING THE EVOLUTION OF HEPATIC STEATOSIS

肝脏中脂肪的积累是酒精、某些药物和糖尿病等疾病引起的早期肝损伤的常见问题。当这种情况发生时，脂肪可以改变肝脏中许多基因和蛋白质的数量。细胞色素P450蛋白质将活性形式的氧插入化学物质中，包括药物和脂肪。然而，在这个过程中，这些活化的化学物质中的一些会损害周围组织。本项目将研究脂肪在肝脏中积累时细胞色素P450水平如何改变的细节。这些发现可能会提示如何恢复细胞色素P450的正常水平，以及如何最大限度地减少肝脏中活化化学物质的有害影响。

The accumulation of fat in liver is a common problem in early liver injury caused by alcohol, certain drugs and diseases like diabetes. When this occurs the fats can change the amounts of a number of genes and proteins in liver. Cytochrome P450 proteins insert an activated form of oxygen into chemicals, including drugs and fats. In the process, however, some of these activated chemicals can damage surrounding tissues. This project will study the details of how the levels of cytochromes P450 are altered when fat accumulates in liver. The findings may suggest ways in which normal levels of cytochromes P450 can be restored and how to minimise the injurious effects of activated chemicals in liver.