YOUNG ADULTS WITH ADDICTION: IMPULSIVITY, BRAIN DYSFUNCTION AND RECOVERY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目将研究15名年轻人（18至25岁），他们目前正在Hazelden Fellowship Club接受可卡因或兴奋剂依赖治疗（以及15名对照组）。我们将研究神经生物学异常，神经认知和冲动，特别是因为它们与恢复过程有关。具体而言，受试者将在两个时间点接受神经认知测试和测量冲动性的任务：在他们住院开始时和约60天时，以评估通过治疗和禁欲的主动过程的大脑恢复。冲动性自我评定量表（Barratt Impulsivity Scale）和测量执行功能的计算机任务都将完成。出于类似的原因，也将在这两个时间点完成脑成像扫描。 研究的脑成像部分将包括MRI扫描和GABA光谱学，这些将在加入Fellowship俱乐部后不久和三个月时进行。虽然参与者基本上是作为他们自己的对照，但我们也会招募年龄、性别、社会经济地位相匹配的健康对照，从而允许将这些测试与正常对照进行比较。同样的测量和扫描可以用对照进行，包括在三个月时重复扫描以测量GABA的正常变化。 该项目的目标是检查可卡因或安非他明依赖（正在接受治疗）的青少年是否比对照组更冲动，以及通过fMRI和GABA光谱学测量来确定可卡因或安非他明滥用人群中存在的潜在大脑异常。基于脑部扫描的结果，我们希望确定这些成瘾受试者在2个月的恢复期内是否出现大脑恢复（例如异常的改善）。通过神经认知测试，我们希望确定这些神经认知和行为冲动的措施是否与GABA水平的改变相关。最后，研究人员将检查在行为测量或功能磁共振成像上观察到的任何变化是否与恢复结果有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will study 15 young adults (ages 18 to 25) who are currently in treatment for cocaine or stimulant dependence at Hazelden Fellowship Club (as well as 15 controls). We will study neurobiological abnormalities, neurocognition and impulsivity particularly as they are associated with the recovery process. Specifically, subjects will undergo neurocognitive testing and tasks measuring impulsivity at two time points: at the beginning of their stay and at approximately 60 days to assess brain recovery through the active process of treatment and abstinence. Both self-rating scales of impulsivity (Barratt Impulsivity Scale) and computer tasks measuring executive functioning will be done. Brain imaging scans would also be completed at these two time points for similar reasons. The brain imaging portion of the study will consist of MRI scans and GABA spectroscopy which will be conducted soon after admission to Fellowship club and at three months. Although the participants would essentially act as their own controls we also would recruit healthy controls matched on age, gender, socioeconomic status and thus would allow comparisons on these tests with normal controls. The same measures and scanning could be done with controls including a repeat scan at three months to measure normal variation in GABA. The goal of this project is to examine whether youth with cocaine or amphetamine dependence (who are in treatment) are more impulsive than controls, as well as to determine the underlying brain abnormalities that exist in people with cocaine or amphetamine abuse as measured by fMRI and GABA spectroscopy. Based on the results of the brain scans, we hope to determine whether brain recovery (e.g. amelioration of abnormalities) occurs in these subjects with addiction over a 2-month period of being in a recovery setting. Through the neurocognitive testing, we hope to determine whether these neurocognitive and behavioral measures of impulsivity are correlated with altered GABA levels. Finally, the researcher will examine if any of the changes observed on behavioral measures or the fMRI are associated with recovery outcomes.