PSYCHOSOCIAL DISRUPTION OF ESTRADIOL ACTION ON BEHAVIOR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 NIMH资助的项目于2009年7月开始，以测试由社会从属关系介导的心理社会压力破坏雌性恒河猴中雌二醇的亲社会和抗焦虑作用的假设。 第一年开始的研究旨在确定雌激素受体（ER）和（注册）激动剂丙基吡唑三醇（PPT）和二芳基丙腈（DPN）的有效剂量范围。 将两种剂量的每一种与两种剂量的雌二醇在一系列雌激素依赖性结果测量上进行比较，包括社交和焦虑样行为、血清LH水平、催产素、催乳素和CSF催产素水平。 数据收集于2009年11月完成，因此分析正在进行中。 然而，迄今为止的数据表明，占主导地位的女性有较高水平的催产素在血清和CSF中，这是增强雌二醇和PPT。 然而，这些药物并不影响下属的催产素水平较低。 这些研究将大大提高我们对压力如何对女性雌二醇的行为功效产生不利影响的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NIMH-funded project was begun in July 2009 to test the hypothesis that psychosocial stress, mediated by social subordination disrupts the prosocial and anxiolytic effects of estradiol in female rhesus monkeys. Studies initiated during the first year was design to determine effective dose ranges for estrogen receptor (ER) ¿ and (registered) agonists, propyl-pyrazole-triol (PPT) and diarylpropionitrile (DPN), respectively. Two doses of each were compared to two doses of estradiol on a range of estrogen-dependent outcome measures, including social and anxiety like behavior, serum levels of LH, oxytocin, prolactin, and CSF levels of oxytocin. Data collection was completed in Nov 2009 so analyses are underway. However, data to date suggest that dominant females have higher levels of oxytocin in serum and CSF and this is enhanced by estradiol and PPT. However, these drugs do not influence the lower levels of oxytocin in subordinates. These studies will greatly enhance our understanding of how stress adversely affects the behavioral efficacy of estradiol in females.