3D Ultrasound for Pediatric Cardiology

描述（由申请人提供）：视觉探索生物医学和新墨西哥大学（UNM）健康科学中心组建了一支跨学科的科学家团队，他们在先天性心脏病诊断，超声图像分析和3D超声重建方面具有丰富的经验。该团队将开发和测试一个系统，以提供3D多视图重建，以提高3D图像质量，并使用常规2D探针对儿童心脏进行定量心功能分析。这种方法的优点是能够使用现成的2D US系统获得心脏结构和关系的完整3D欣赏。先天性心脏缺陷（CHD）是最常见的出生缺陷类型，在美国每1000个出生的婴儿中就有8个。在出生后第一年，冠心病造成的死亡比任何其他出生缺陷都要多。我们的3D重建技术将为非心脏病医生提供一种工具，用于早期筛查和检测冠心病，使用更容易获得的2D美国成像技术。第一阶段有三个具体目标要完成。第一个目标是改进和验证二维手绘超声心动图序列的多视图三维重建自动算法。第二个目标是收集10个受试者的二维超声心动图序列，并评估重建三维体的配准算法的性能。第三个目的是重建左心室，定量分析心功能。最终的产品是一个软件插件，可以使用市售的2D超声仪渲染精确的3D体积。我们的商业化策略是在第二阶段将3D重建软件集成到现有的商业超声波中。

DESCRIPTION (provided by applicant): Vision Quest Biomedical and the University of New Mexico (UNM) Health Science Center have assembled a team of inter-disciplinary scientists with experience in congenital heart disease diagnosis, ultrasound image analysis, and 3D ultrasound reconstruction. This team will develop and test a system to provide 3D multi-view reconstruction for improved 3D image quality and quantitative cardiac function analysis of children hearts using a regular 2D probe. The advantage of this approach is the ability to obtain a full 3D appreciation of cardiac structures and relationships using readily available 2D US systems. Congenital heart defects (CHD) are the most common type of birth defect and present in about 8 of every 1,000 babies born in the United States. CHD is responsible for more deaths in the first year of life than any other birth defect. Our 3D reconstruction technology will give the non- cardiologist physician a tool for early screening and detection of CHD, using more readily available 2D US imaging technology. There are three specific aims to be accomplished in Phase I. The first aim is to improve and validate the automatic algorithm for multi-view 3D reconstruction from 2D freehand echocardiography sequences. The second aim is to collect 2D echocardiography sequences, from 10 subjects and assess performance of registration algorithm for reconstructed 3D volumes. The third aim is to reconstruct the left ventricle for quantitative analysis of cardiac function. The final product is a software plug-in that can be used to render accurate 3D volumes using commercially available 2D ultrasound machines. Our commercialization strategy is to integrate the 3D reconstruction software into an existing commercial ultrasound in Phase II. PUBLIC HEALTH RELEVANCE: Congenital heart defects (CHD) are the most common type of birth defect and present in about 8 of every 1,000 babies born in the United States. CHD is responsible for more deaths in the first year of life than any other birth defect. In this project, we will develop a 3D multi-view reconstruction system to provide improved 3D image quality and quantitative cardiac function analysis of children hearts using a regular 2D probe.