OTHER FUNCTIONS - IMPLANTABLE BATTERYLESS PACEMAKER AND TELEMETRY DEVICE FOR SMA

心律失常是主要的公共卫生负担。在美国，每年有250，000 - 400，000例心源性猝死（SCD），占成人所有死亡的20%;其中大多数是由于心室颤动。此外，目前约有250万美国人患有心房颤动（AF），预计到2050年将超过500万。强有力的证据表明，SCD和AF的风险都包括一个突出的遗传因素。转基因小鼠是研究心律失常和心力衰竭机制的有力模型。在大型动物中，临床起搏器可用于开发慢性AF或起搏诱导的心力衰竭等模型。然而，由于缺乏微型植入式起搏器，在转基因或基因敲除小鼠中开发类似的模型是不可能的。现有的用于小动物心脏监测的植入式遥测设备要么太大、太重，要么电池寿命不足。此外，这些设备无法起搏心脏，这对于上述模型的开发至关重要。该合同的目标是开发一种小型（<1cc），重量轻（<1g），无电池，无线可编程的植入式设备，用于体内刺激和监测小鼠和其他小动物的心脏电活动。通过谐振感应功率传输的无电池操作和标准小鼠笼的无线操作，这样的设备将适用于小鼠的长期、非卧床起搏和ECG监测。

Cardiac arrhythmias are a major public health burden. There are 250,000 - 400,000 sudden cardiac deaths (SCD) in the US every year, accounting for up to 20% of all deaths in adults; the majority of these are due to ventricular fibrillation. In addition, approximately 2.5 million Americans now suffer atrial fibrillation (AF), a number that is expected to surpass 5 million by 2050. Strong evidence indicates that risk for both SCD and AF include a prominent genetic component. Genetically-modified mice are a powerful model to study mechanisms underlying cardiac arrhythmias and heart failure. In larger animals, clinical pacemakers can be used to develop models of chronic AF or pacing-induced heart failure, among others. However, it has not been possible to develop similar models in transgenic or knockout mice due to the lack of availability of miniature, implantable pacemakers. Existing implantable telemetry devices for cardiac monitoring in small animals are either too large, too heavy, or have inadequate battery life. Moreover, these devices are not able to pace the hearts, which is essential for the development of the above models. The goal of this contract is to develop a small (<1cc), light-weight (<1gram), batteryless, wireless programmable implantable device for in vivo stimulation and monitoring of cardiac electrical activity in mice and other small animals. With batteryless operation by resonant inductive power transfer and wireless operation with a standard mouse cage, such a device will be suitable for long-term, ambulatory pacing and ECG monitoring in mice.