Three-day scientific conference to be held April 18-20, 2012

大脑对能量的需求非常高。大多数（如果不是全部的话）神经系统疾病都表现为脑能代谢异常，但人们对脑能代谢异常如何导致神经系统疾病知之甚少。这种知识差距部分源于大脑能量通路和机制的高度复杂性和异质性。本次会议的目标是确定这一领域可处理的知识空白，特别强调目前可用于体外和体内能量代谢高分辨率成像的新技术。为此，我们将邀请具有脑生物能量学、相关前沿技术和特定疾病病理生理学专业知识的演讲者。我们提出一个项目，在一个非常互动的论坛上，将来自研究领域的研究人员聚集在一起，否则他们将很少有互动：临床医生、神经科学家、线粒体生理学家和技术先驱。新的成像技术现在允许在实验疾病模型中进行细胞类型特异性和单细胞分辨率的大脑能量代谢，非侵入性成像方法继续提高我们评估体内与疾病和衰老相关的代谢和功能变化的能力。为了促进这一领域的进展，重要的是技术先驱者向重要的受众介绍这些进展，并教育面向疾病的研究人员了解这些新方法的可用性、能力和局限性。没有其他会议能达到这一目的。我们在此提议的ICBEM会议将为这些跨学科互动提供一个独特的场所：例如，体内成像专家与神经疾病专家和可能挑战体内成像固有假设的顽固基础科学家进行对话；在线粒体生理学和脑能量学方面具有专业知识的基础科学家批评人类遗传学研究，将因果关系分配给线粒体和其他基因突变；对于基础科学家和技术先驱来说，他们可以拿走关注疾病的研究人员正在解决的关键问题。会议大纲/主题：1 .正常神经传递中脑能量代谢的细胞间区隔化。2。测量大脑生物能量学的新兴技术。3。正常衰老对脑能量学的影响。神经系统疾病中的脑能量学-急慢性炎症-阿尔茨海默病-微血管痴呆-帕金森病及相关疾病

DESCRIPTION: Brain energy requirements are exceedingly high. Most, if not all neurological disorders manifest abnormalities in brain energy metabolism, but remarkably little is known about how these abnormalities in brain energy metabolism contribute to neurological disorders. This knowledge gap stems in part from the high degree of complexity and heterogeneity of brain energetic pathways and mechanisms. The goal of this meeting is to identify tractable knowledge gaps in this area, with special emphasis on new technologies now becoming available for high-resolution imaging of energy metabolism in vitro and in vivo. To this end we will invite speakers with expertise in brain bioenergetics, relevant cutting-edge technology, and specific disease pathophysiology. We propose a program that pulls together, in a very interactive forum, investigators from research areas who would otherwise have little interaction: clinicians, neuroscientists, mitochondrial physiologists, and technology pioneers. New imaging technologies now permit cell-type specific and single cell resolution of brain energy metabolism in experimental disease models, and non-invasive imaging methods continue to improve our ability to evaluate metabolic and functional changes associated with disease and aging in vivo. To facilitate progress in this field it is important that the technology pioneers present these advances to a critical audience, and that disease-oriented researchers become educated as to the availability, capacities, and limitations of these new methodologies. There is no other meeting or conference that serves this purpose. The ICBEM meeting we propose here will provide a unique venue for these cross-disciplinary interactions: e.g. for in vivo imaging specialists to converse with experts in neurological diseases and with hard-nosed basic scientists who may challenge some assumptions inherent in vivo imaging; for basic scientists with expertise in mitochondrial physiology and brain energetics to critique human genetics studies assigning cause- effect relationships to mitochondrial and other gene mutations; and for basic scientists and technology pioneers to take away the key questions being addressed by the disease-focused researchers. Outline of Sessions/Topics: I. Intercellular compartmentalization of brain energy metabolism in normal neurotransmission. II. Emerging technologies for measuring brain bioenergetics. III. Effects of normal aging on brain energetics. IV. Brain energetics in neurological disorders - acute & chronic inflammation - Alzheimer's diseases- microvascular dementia - Parkinsons' and related diseases PUBLIC HEALTH RELEVANCE: This research conference will promote our understanding of how changes in energy metabolism affect brain function in neurological disease and normal aging. The conference will provide a forum for neuroscientists and disease-focused investigators to learn about and critique emerging technologies in high resolution brain metabolism imaging, and will allow technology pioneers to learn about the key questions facing neuroscientists and disease-focused investigators. These interactions are important for facilitating progress in these research areas. Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.