2011 Plant Metabolic Engineering GRC/GRS

描述（由申请人提供）：植物生产超过200,000种天然产品，为开发治疗世界上最严重疾病的新疗法提供基础。世界上大约75%的人依靠药用植物提供初级药学服务。天然产物是药物开发的丰富资源，占抗癌药物的60%，占感染性疾病药物的75%。鉴于手性中心的多样性、修饰取代基的精化以及这些化合物在植物和环境之间的重要调解作用，天然产物在所有药物的设计和开发中发挥着重要作用。当前的后基因组时代为操纵植物化学提供了新的机会，这将进一步影响全球食物供应的水平和营养成分，并导致新药和治疗化合物的开发。为了建立一个多学科合作的环境，以揭示植物天然产物生物合成的复杂性，植物代谢网络的动力学，并推进植物代谢工程的基础和应用研究，以支持药物开发活动，我们请求支持将于7月24日至29日举行的2011年戈登研究会议（GRC）和植物代谢工程联合研究生研究研讨会（GRS）。2011年，沃特维尔谷会议中心（NH）。与本系列会议之前的会议类似，我们预计来自美国和国外的175名演讲者和参与者，来自各个职业水平，代表来自学术界，工业界，私人机构和联邦实验室的机构。将继续共同努力，鼓励妇女、残疾人和来自代表性不足群体的科学家参与。我们将在GRC之前立即举办研究生研究研讨会（GRS）。GRS为博士生和博士后提供了一个独特的场所，在同行的环境中展示他们的研究，学习发展新的研究思路，并建立一个充满活力和互动的科学社区，因为GRS参与者完全融入了更大的GRC会议。2011年的GRS将以“圆桌讨论”为中心，与会者有机会公开讨论与该领域有关的问题，以及未来的发展方向，从而使与会者能够建立一个领域、一个社区和一个会议场所的所有权。GRS的所有参与者都希望留在GRC，进一步加强这次会议的教育成分。

DESCRIPTION (provided by applicant): Plants produce over 200,000 natural products that provide the basis to develop novel therapeutic agents to treat the world's most serious ailments. Roughly 75% of the world relies on medicinal plants for primary pharmaceutical care. Natural products are rich resources for drug development comprising 60% of anticancer compounds and 75% of drugs for infectious diseases. Given the multiplicity of chiral centers, elaboration with modifying substituents and important roles these compounds mediate between plants and environment, natural products play an important role in the design and development of two-thirds of all drugs. The current post- genomic era presents new opportunities for manipulating plant chemistry that will further impact the level and nutritional content of global food supply and lead to the development of novel drugs and therapeutic compounds. To establish a setting for advancement of multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis, the dynamics of plant metabolic networks, and advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2011 Gordon Research Conference (GRC) and joint Graduate Research Seminar (GRS) on Plant Metabolic Engineering to be held July 24-29, 2011 at the Waterville Valley conference center (NH). Similar to prior meetings of this conference series, we expect 175 speakers and participants from the US and abroad, at all career levels, representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. We will host a Graduate Research Seminar (GRS) immediately prior to the GRC. The GRS provides a unique venue for Ph.D. students and postdoctoral fellows to present their research in a setting of their peers, learn to evolve new research ideas, and build a dynamic and interactive scientific community as the GRS participants are fully integrated into the larger GRC meeting. The 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue. All participants to the GRS are expected to stay for the GRC, further enhancing the educational component of this conference. PUBLIC HEALTH RELEVANCE: Plants produce natural products, many of which have a profound and lasting impact on human health. 75% of the world's population relies upon medicinal plants for its primary pharmaceutical care including anticancer compounds and drugs for infectious diseases. The GRC in Plant Metabolic Engineering provides a setting for developing the multidisciplinary collaborations and interactions needed to unravel the complexity of plant metabolism in support of drug development activities, food nutrition, energy production and agronomic production of plants. The preceding 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue.