FASEB SRC on The Basic Origins and Medical Consequences of Protein Aggregation

描述(由申请人提供)：这份R13提案请求为第八届国际淀粉样蛋白错误折叠与疾病国际会议FASE B提供核心支持。这次会议的题目是“蛋白质聚集的基本起源和医学后果”，将于2011年6月12日至6月17日在科罗拉多州的斯诺马斯村举行。这次会议将促进大约150名参与者之间的个人互动，他们参与了有关蛋白质错误折叠疾病的研究，如阿尔茨海默氏症、帕金森氏症、亨廷顿氏症和II型糖尿病。参与者将包括化学家、结构生物学家、生物化学家、细胞生物学家、使用动物模型的研究人员，以及治疗淀粉样蛋白疾病患者的临床医生。尽管所有与会者都对蛋白质错误折叠疾病有共同的兴趣，但他们的不同背景将使他们中的许多人无法在其他会议上作为一个小组聚集在一起。因此，这次会议将为跨学科交流提供一个独特的场所，这似乎是全面捕捉由特定异常蛋白质结构引起的疾病的所有方面所必需的，这些结构反过来又会在细胞和器官水平上造成毒性。 与公共健康相关：蛋白质通过采用或折叠成精确的三维结构来发挥其生物学功能。错误折叠的蛋白质不仅会失去功能，还会变得有毒。这种现象在包括阿尔茨海默氏症、帕金森氏症和II型糖尿病在内的一系列疾病中都能发现。为了设计诊断和治疗策略，拟议中的会议将促进研究蛋白质结构变化的科学家与研究毒性影响的科学家以及治疗患者的内科科学家之间的交流。

DESCRIPTION (provided by applicant): This R13 proposal requests core support for the eighth international FASEB conference on amyloid protein misfolding and disease. The meeting is entitled "The Basic Origins and Medical Consequences of Protein Aggregation", and will be held June 12th to June 17th, 2011 in Snowmass Village, Colorado. The conference will promote personal interaction between approximately 150 participants who are involved in studies concerning protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and type II diabetes. Participants will include chemists, structural biologists, biochemists, cell biologists, researchers who use animal models, and clinicians who treat patients afflicted with amyloid diseases. Although all participants share a common interest in protein misfolding diseases, their diverse backgrounds would prevent many of them from gathering as a group at other meetings. Thus, the conference will provide a unique venue for an interdisciplinary exchange that appears necessary to fully capture all aspects of diseases that are caused by specific aberrant protein structures that, in turn, cause toxicity at the cellular and organ levels. PUBLIC HEALTH RELEVANCE: Proteins perform their biological functions by adopting, or folding, to a precise three dimensional structure. Misfolded proteins can not only lose their function, but can become toxic. This phenomenon is found in a spectrum of diseases that include Alzheimer's, Parkinson's, and type II diabetes. In order to devise diagnostic and treatment strategies, the proposed conference will promote exchange among scientists who study protein structural changes with those that study toxic effects, as well as physician-scientists who treat patients.