2011 Cilia, Mucus & Mucociliary Interactions Gordon Research Conference

描述（由申请人提供）：本提案寻求对将于2011年2月13日至18日在加利福尼亚州文图拉举行的“纤毛、粘液和粘膜纤毛相互作用”会议的部分支持。这是一个批准的戈登研究会议（GRC）后，成功的GRC主办的同一标题的会议在2005年2月，2007年和2009年举行。这次会议是独特的，其重点纤毛，粘液和粘液纤毛的相互作用。这些领域代表了彼此高度相关的专业科学学科，但很少合并成一个单一的科学会议。近年来，人们越来越认识到这些相互联系在生物学、生理学、功能和疾病方面的科学重要性。在过去的十年中，在对纤毛发育、特性和功能的基本理解方面取得了重大进展;上皮细胞分化;粘蛋白调节、产生和分泌;以及粘液功能和相互作用，这增加了在分子水平上进行治疗干预的可能性。本次会议上的思想交流是该领域的推动力，主要影响呼吸道疾病，例如原发性纤毛运动障碍，囊性纤维化，支气管炎和支气管炎，慢性阻塞性肺病，哮喘和慢性鼻窦炎。这个GRC会议是一个论坛，来自不同学科的基础和临床研究人员会面，互动，并将新的基础研究成果带到转化阶段。一般的组织是基于既定的和非常成功的GRC公式。本次会议的目的是：1）汇集世界权威和年轻科学家在纤毛和粘液的基本过程，包括纤毛组装和功能，上皮细胞的发育和分化，粘液/粘蛋白在液体和粘膜凝胶中的功能，粘液纤毛粘附和运输的原则，以及相关的疾病病理过程的学科; 2）提供一个论坛，介绍新的研究成果和技术，交流思想，并刺激基础，翻译和临床研究人员之间的新合作; 3）通过使用包括结构和数学建模在内的各种方法将研究人员聚集在一起，整合新知识，生物工程、成像和计算遗传学;以及4）通过会议的合理规划和组织，确保妇女、少数民族和年轻研究人员（初级教师、研究员、博士前和博士后学生）的代表性。会议开始与纤毛，粘液和mucociliary相互作用的前景和主题介绍。它继续与会议上纤毛和粘液成分的发展;信号和转录控制;粘液和纤毛的基本过程;理解粘液纤毛疾病的遗传方法;纤毛，粘液和粘液纤毛相互作用的疾病;纤毛和粘液的结构-功能关系;粘液纤毛相互作用;和生活在界面：纤毛和流体的相互作用。 公共卫生相关性：粘液纤毛系统是哺乳动物呼吸道的主要防御机制之一，因为粘液捕获空气传播的病原体和毒素，并且下面的流体层中纤毛的协调跳动驱动粘液层向上，使得它可以被吞咽。然而，由呼吸道细胞产生的粘液的数量或物理化学性质的异常，或者纤毛组装或结构的遗传缺陷，导致粘液阻塞气道并导致呼吸道疾病。本次会议汇集了纤毛，粘液和粘液纤毛相互作用的专家，以更新这些领域的进展，并激发新的方法来更好地了解它们对健康和疾病的影响。

DESCRIPTION (provided by applicant): This proposal seeks partial support for a conference on "Cilia, Mucus and Mucociliary interactions" to be held in Ventura, CA from February 13 to 18, 2011. This is an approved Gordon Research Conference (GRC) following successful GRC-sponsored conferences of the same title held in February 2005, 2007, and 2009. This conference is unique in its focus on cilia, mucus and mucociliary interactions. These fields represent specialized scientific disciplines that are highly relevant to each other, yet are rarely combined into a single scientific conference. The scientific importance of these interconnections with respect to biology, physiology, function and disease has been increasingly recognized in recent years. The past decade has seen major advances in the basic understanding of ciliary development, properties and function; epithelial cell differentiation; mucin regulation, production and secretion; and mucus functions and interactions that have increased possibilities for therapeutic intervention at the molecular level. The exchange of ideas at this conference is a driving force for this field that impacts primarily on diseases of the respiratory tract, e.g. primary ciliary dyskinesia, cystic fibrosis, bronchitis and bronchorrhea, chronic obstructive pulmonary diseases, asthma and chronic rhinosinusitis. This GRC conference is a forum where basic and clinical researchers from diverse disciplines meet, interact, and bring new basic findings to the translational stage. The general organization is based on the established and very successful GRC formula. The objectives of this conference are: 1) To bring together world authorities and young scientists in the disciplines of fundamental process in cilia and mucus including ciliary assembly and function, epithelial cell development and differentiation, mucus/mucin function in fluids and mucosal gels, principles of mucociliary adhesion and transport, and related pathologic processes in diseases; 2) To provide a forum for presentation of new research findings and technologies, exchange of ideas, and the stimulation of new collaborations among basic, translational, and clinical researchers; 3) To integrate new knowledge by bringing together investigators using a diverse range of approaches including structural and mathematical modeling, bioengineering, imaging and computational genetics; and 4) To assure strong representation of women, minorities, and young investigators (junior faculty, fellows, predoctoral and post-doctoral students) through sound planning and organization of the meeting. The conference opens with presentations of Prospects and Themes for cilia, mucus, and mucociliary interactions. It continues with sessions on Development of ciliary and mucous components; Signaling and transcriptional control; Fundamental processes in mucus and cilia; Genetic approaches to understanding mucociliary diseases; Diseases of cilia, mucus, and mucociliary interactions; Structure-function relationships in cilia and mucus; Mucociliary interactions; and Life at the interface: cilia and fluid interactions. PUBLIC HEALTH RELEVANCE: The mucociliary system is one of the primary defense mechanisms of mammalian respiratory tracts, as mucus traps air-borne pathogens and toxins and the coordinated beating of cilia in the underlying fluid layer drives the mucus layer upward so that it can be swallowed. However, abnormalities in either quantity or physicochemical properties of the mucus produced by cells of the respiratory tract, or genetic defects in ciliary assembly or structure, leads to airway obstruction by mucus and resultant respiratory tract diseases. This conference brings together experts on cilia, mucus, and mucociliary interactions to update progress in these areas and stimulate new approaches to better understanding their impact on health and diseases.