2011-2013 Metals in Biology GRC and Bioinorganic GRS

描述（由申请人提供）：该提案要求资金支持2011年1月至2013年2月的生物学戈登研究会议（MIB GRC）中的金属，以及2011年2月至2013年2月的生物无机化学（GRS）相关研究生研究研讨会。MIB GRC为生物无机化学前沿研究的讨论提供了主要论坛。它是该领域的核心会议，是一个“旗舰”，领先的GRC具有85%的绩效评级（2008年数据），并且一直超额认购，即使它自1962年以来一直满足。GRS成立于1996年，目的是为研究生和博士后提供一个论坛，让他们参加与“父”MIB GRC重叠的会议（一个晚上），但也独立运行。这种组织结构确保了学生和博士后与领先的研究人员互动，同时发展自己的社区意识，为该领域未来的领导者提供了一种手段。为期两天半的GRS由年轻的研究人员在相关GRC的领先科学家的支持下组织。 这两次会议的中心主题是需要了解金属离子在不同生物系统中发挥的关键作用。具体而言，金属离子对超过三分之一的酶的功能至关重要，并且参与许多重要的生物合成途径，包括电化学能量到化学能量的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。关于金属酶功能的分子水平的细节出现在化学，生物学和物理学的界面上，来自多个互补的研究领域。对金属生物化学的透彻理解对于开发潜在的诊断工具和治疗阿尔茨海默病、帕金森病和癌症等疾病的药物靶点至关重要。在正式讲座和非正式的互动在独特的戈登研究会议格式这些问题的讨论有效地传播了在该领域的研究前沿发现的知识，促进合作，并提高了该领域的凝聚力，尽管其高度多学科的性质。 公共卫生相关性：会议的中心主题是需要了解金属离子在不同生物系统中发挥的关键作用。具体而言，金属离子对超过三分之一的酶的功能至关重要，并且参与许多重要的生物合成途径，包括电化学能量到化学能量的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。对金属生物化学的透彻理解对于开发潜在的诊断工具和治疗阿尔茨海默病、帕金森病和癌症等疾病的药物靶点至关重要。

DESCRIPTION (provided by applicant): This proposal requests funds to support the Metals in Biology Gordon Research Conference (MIB GRC) in Jan-Feb, 2011-2013, and the associated Graduate Research Seminar in Bioinorganic Chemistry (GRS) in February, 2011-2013. The MIB GRC provides the principal forum for the discussion of research at the forefront of bioinorganic chemistry. It is the core meeting for the field, is a 'flagship', leading GRC with an 85% performance rating (2008 data), and is consistently oversubscribed even though it has met consistently since 1962. The GRS was established in 1996 in order to provide a forum for graduate students and postdocs to participate in a meeting that overlaps with the "parent" MIB GRC (for one evening), yet also runs independently. This organizational structure ensures that the students and postdocs interact with leading researchers while developing their own sense of community, providing a means for future leaders of the field to emerge. The two and a half day GRS is organized by young investigators with the support of leading scientists from the associated GRC. A central theme of both meetings is the need to understand the critical role that metal ions play in diverse biological systems. Specifically, metal ions are critical for the function of over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular-level details regarding metalloenzyme function emerge from multiple complementary lines of study, at the interface of chemistry, biology, and physics. A thorough understanding of metallobiochemistry is critical to the development of potential diagnostic tools and drug targets for the treatment of diseases such as Alzheimer's, Parkinson's, and cancer. Discussion of these issues in formal lectures and informal interactions in the unique Gordon Research Conference format effectively disseminates knowledge of discoveries at the forefront of research in the field, fosters collaborations, and improves the cohesiveness of the field, notwithstanding its highly multidisciplinary nature. PUBLIC HEALTH RELEVANCE: A central theme of the meetings is the need to understand the critical role that metal ions play in diverse biological systems. Specifically, metal ions are critical for the function of over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. A thorough understanding of metallobiochemistry is critical to the development of potential diagnostic tools and drug targets for the treatment of diseases such as Alzheimer's, Parkinson's, and cancer.