Spore in Head and Neck Cancer

本次申请为约翰·霍普金斯大学医学院的头颈部癌症卓越研究专业项目(孢子)继续申请，支持一个高度互动、多学科和机构内的项目。我们提出了五个研究项目、三个核心、一个职业发展和一个研究发展计划，以开展我们的头颈癌转化性研究。孢子在所有项目中都注意到HPV感染的存在和不存在，作为疾病生物学和行为的主要决定因素。此外，有两个主题渗透到我们的主要项目中，一个是基因组学和生物学，另一个是免疫学。 研究项目1--通过抑制5型磷酸二酯酶增强对头颈部鳞状细胞癌的免疫反应--联合调查者，Ivan Borrello(基础)和Joseph Califano(临床)。研究项目2--从癌症基因组学到个性化生物标记物的HNSCC。-联合调查员David Sidransky(Basic)和Nishant Agrawal(诊所)。研究项目#3-通过对抗转化生长因子-β介导的免疫抑制来改善HNSCC的EGFR靶向免疫治疗--共同研究员Christine Chung(临床)和ATUI Bedl(基础)。研究项目4-HPV疫苗治疗-共同调查者Sara Pal(临床)和T.C.Wu(基础)项目5-头颈部鳞状细胞的病原学异质性-联合调查者Gypsyamber D‘Souza(基础)和Carole Fakhry(临床) 这些核心支持研究计划(核心#1-病理学/组织核心，韦斯特拉博士；核心#2-行政/临床核心(西德兰斯基博士)，核心#3-生物统计学和生物信息学核心(罗斯纳博士))职业发展计划(西德兰斯基博士)帮助新的研究人员的出现，研究发展计划(大卫·西德兰斯基博士)为创新方向提供快速资金。

This application for continuation for the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer at the Johns Hopkins University School of Medicine supports a highly interactive, multidisciplinary, and intrainstitutional program. Five research projects, three cores, a career development and a research developmental program are proposed to carry out our translational research in head and neck cancer. The SPORE has given attention in all projects to the presence and absence of HPV infection as a major determinant of disease biology and behavior. Moreover, there are two main themes that permeate our major projects, one is genomics and biology and the other is immunology. Research Project #1- Augmentation of Immune Response to Head and Neck Squamous Cell Carcinoma via Phosphodiesterase Type 5 Inhibition - Co-Investigators, Ivan Borrello (basic) and Joseph Califano (clinic). Research Project #2 - HNSCC From Cancer Genomics to Personalized Biomarkers. - Co-Investigators, David Sidransky (basic) and Nishant Agrawal (clinic). Research Project #3 - Improving EGFR-targeted Immunotherapy of HNSCC by Counteracting TGF- ¿ -mediated Immune Suppression - Co-Investigators, Christine Chung (clinic) and AtuI Bedl (basic). Research Project #4 - HPV Vaccine Therapy - Co-Investigators Sara Pal (clinic) and T.C. Wu (basic) Project #5 - Etiologic Heterogeneity in Head and Neck Squamous - Co-Investigators, Gypsyamber D'Souza (basic) and Carole Fakhry (clinic) The cores support the research programs (Core #1 - Pathology/ Tissue Core, Dr. Westra; and Core #2 - Administrative/Clinical Core (Dr. Sidransky), Core #3 - Biostatistics and Bioinformatics Core (Dr. Rosner) The Career Development Program(Dr. Sidransky) aids the emergence of new investigators and the Research Developmental Program (Dr. David Sidransky) provides rapid funding of innovative directions.