CANCER CELL BIOLOGY

项目总结 Winship癌症研究所的癌症细胞生物学(CCB)项目研究细胞转化导致的人类细胞生物学功能的变化。CCB项目由来自埃默里大学15个系的36名核心成员组成，其中包括医学和公共卫生学院以及埃默里学院。 CCB计划有两个主题：1)细胞生存和死亡机制，2)细胞黏附、沟通和转移。CCB计划是Winship的科学总机，是发现新的信号通路及其生物学验证的平台，并在CGE、DDT和CPC计划之间交换概念。旨在提高凝聚力和清晰度的战略重组有助于使当前的项目期对建行项目来说是一个富有成效的时期。CCB实验室识别并瞄准了涉及各种特定疾病部位癌症的关键分子途径。它的成员出版了300份与癌症有关的出版物，其中许多发表在影响力很大的期刊上。该计划进一步推动了重要举措，包括建立In Silico脑瘤研究中心。 建行成员利用来自内部试点赠款的启动资金，将试点科学扩展为国家资助的项目。CCB计划成员目前有23,452,748美元的研究资助(年度直接成本)，其中19,909,676美元是同行评审，9,489,373美元是NCI资助的。 作为Winship的科学交流平台，CCB计划的生产力是所有研究计划的胜利，并促进了重要的计划间合作。该计划在当前项目期间出版了300份与癌症有关的出版物，其中大部分发表在有影响力的期刊上。其中，大约或接近15%代表方案内互动，38%代表方案间互动。建行成员和合作者为癌症领域做出了贡献 在许多重要的方面进行研究，该计划将在下一个项目期继续取得成功。

PROJECT SUMMARY The Winship Cancer Institute's Cancer Cell Biology (CCB) Program studies the changes in biological function of human cells as a result of cell transformation. The CCB Program consists of 36 core members from 15 departments across Emory University, including the Schools of Medicine and Public Health and Emory College. The CCB program has two main themes: 1) Cell Survival and Death Mechanisms, and 2) Cell Adhesion, Communication and Metastasis. The CCB Program serves as Winship's scientific switchboard, a platform for discovery of novel signaling pathways, their biological validation, and an interchange of concepts among the CGE, DDT, and CPC Programs. Strategic reorganization toward increased cohesion and clarity has helped make the current project period a highly productive one for the CCB Program. CCB labs identified and targeted key molecular pathways involved in a variety of disease site-specific cancers. Its members published 300 cancer-related publications, many of which appeared in high-impact journals. The program furthered important initiatives, including the establishment of the In Silico Brain Tumor Research Center. Using start-up funding from internal pilot grants, CCB members expanded pilot science into nationally funded projects. CCB Program members currently have $23,452,748 in research grant funding (annual direct costs), of which $19,909,676 is peer-reviewed and $9,489,373 is NCI funded. As Winship's platform for scientific exchange, the CCB Program's productivity has been a win for all of the research programs and has spurred important inter-programmatic collaborations. The program has published 300 cancer-related publications in the current project period, most of which appeared in influential journals. Among these, approximately or neariy 15% represent intra-programmatic and 38% represent inter-programmatic interactions. CCB members and collaborators have contributed to the field of cancer research in a number of significant ways, and the program is poised for continued success going into the next project period.