Smart Optical Sensor for Detection of Cervical Cancer In the Developing World

宫颈癌每年影响全球530，000名妇女的生活，并导致超过270，000人死亡， 其中约85%发生在发展中国家。宫颈癌发病率的下降， 发达国家一直依赖于定期筛查，这种筛查依赖于多次访视、基于细胞学的方法- 巴氏涂片，随后在有指征时进行阴道镜下活检，如果 必要采用这些方法需要专门的诊所访视，以进行标本采集、随访和治疗， 以及病理学实验室和熟练的工作人员，这在资源有限的情况下是不可行的。有一个关键的全球 需要一种在资源匮乏社区有效的筛查和诊断模式。理想的替代品 细胞学检查和阴道镜检查将是低成本、便携式和临床兼容的传感器 并快速且非破坏性地识别用于活检的可疑区域。我们建议开发一种便携式、低功耗 消耗光谱设备，可以用来获得准确和可再现的定量测量 吸收和散射系数，用于宫颈癌筛查，以促进全球健康。我们将评估 通过在海地进行的现场研究，在低资源环境下评估该器械的能力和临床可用性。

Cervical cancer affects the lives of 530,000 women worldwide each year and results in more than 270,000 deaths, with approximately 85% of these deaths occurring in developing countries. The decrease in the incidence of cervical cancer in developed countries has been attributed to regular screening that relies on a multi-visit, cytology-based approach - Papanicolaou (Pap) smear, followed at a later time by colposcopically directed biopsy when indicated, and treatment if necessary. Employing these methods requires dedicated clinic visits for specimen collection, follow up and treatment, as well as a pathology laboratory and skilled staff, which is not feasible in resource limited settings. There is a critical global need for a screening and diagnostic paradigm that is effective in low-resource communities. The desired replacement for cytology and colposcopy would be a low cost, portable and clinically-compatible sensor that can survey the entire cervix and identify suspicious areas for biopsy quickly and non-destructively. We propose to develop a portable, low power consumption spectroscopic device that can be used to obtain accurate and reproducible quantitative measurements of absorption and scattering coefficients with applications to screening of cervical cancers for global health. We will evaluate the capacity and clinical usability of the device in a low-resource setting through a field study in Haiti.