Meharry Medical College Minority-Based Community Clinical Oncology Program

描述（由申请人提供）：本申请是梅哈里医学院（MMC）第9-13年少数族裔社区临床肿瘤学项目（MBCCOP）的第二次更新。该项目开展的临床研究方案来源于NCI批准的CCOP研究基地，包括东部肿瘤合作小组（ECOG）、国家外科辅助乳房项目（NSABP）、妇科肿瘤小组（GOG）、德克萨斯大学MD安德森医院（MDA）、美国外科肿瘤学会小组（ACOSOG）和国家癌症研究所临床试验支持小组（CTSU）。2010年，我们增加了ACOSOG作为研究基地，以容纳加入我们MBCCO的社区外科肿瘤学家。所有这些研究基地试验都是癌症治疗和癌症预防与控制的国家研究。这些试验中的每一个都有与试验的癌症生物学相关的试验特定的纳入和排除标准。mmcs是一所历史悠久的黑人学院和大学（HBCU），自1876年以来一直服务，其使命是促进种族和少数民族的专业培训。MMC的主要临床护理地点是位于梅哈里的纳什维尔总医院（NGH），主要照顾服务不足和贫困的患者，其中种族和少数民族的患病率很高。作为一个以少数民族为基础的CCOP， MMC来自田纳西州戴维森县，这是一个基本上由少数民族组成的地区。在我们的癌症项目中，有色人种患者约占所有接受治疗的血液学/肿瘤学患者的49%。在MMMC MBCCOP的历史中，非裔美国患者占试验累计人数的55%，这一比例几乎与我们的总体患者群体相同，表明少数族裔进入临床试验没有偏见或困难。因此，MMC MBCCOP成功地按照少数民族在我们医疗中心的患病率比例纳入了少数民族受试者。最近注意到西班牙裔患者；越来越多的人在国家医院寻求治疗，并开始进入临床试验。妇女按其疾病流行程度参加所有试验，与男子相比，参加乳腺癌和GOG试验的人数要多得多。从历史上看，参加临床试验的患者中有60%是女性根据最活跃的乳腺癌治疗试验来看，这是一个扭曲的比率。在本申请的报告期内，非裔美国人的患病率评估进入了NGH的临床试验，所有研究方案的所有临床试验中女性的百分比与我们的总结趋势相似。除了临床试验之外，MBCCOP还利用其他资金建立了1)针对少数族裔医生的血液学/肿瘤学奖学金机会，2)针对服务不足人群的癌症问题的同行评审资助研究工作，包括全国演讲和最近授予的P20项目，研究服务不足人群的治疗后“生存”。

DESCRIPTION (provided by applicant): This application is the second renewal of the Minority-Based Community Clinical Oncology Program (MBCCOP) of Meharry Medical College (MMC) for years 9-13. The program conducts clinical research protocols derived from NCI approved CCOP research bases including the Eastern Cooperative Oncology Group (ECOG), the National Surgical Adjuvant Breast Program (NSABP), the Gynecology Oncology Group (GOG), the University of Texas MD Anderson Hospital (MDA), the American College of Surgery Oncology Group (ACOSOG) and the Clinical Trials Support Unit (CTSU) of the National Cancer Institute. In 2010, we added the ACOSOG as a research base to accommodate a community based surgical oncologist who has joined our MBCCO. All of these research base trials are national studies of cancer treatment and cancer prevention and control. Each of these trials has trial specific inclusion and exclusion criteria that relate to the cancer biology of the trial. MMCis a Historically Black College and University (HBCU) in continuous service since 1876 whose mission is to facilitate the professional training of racial and ethnic minorities. The main clinicl care site of MMC is the Nashville General Hospital at Meharry (NGH) that predominantly cares for underserved and indigent patients with a high prevalence of racial and ethnic minorities. As a minority based CCOP, MMC draws from Davidson County Tennessee, a region that is substantially composed of minorities. In our cancer program, patients of color represent approximately 49% of all hematology/oncology patients presenting for care. Over the history of the MMMC MBCCOP, African- American patients represented 55% of trial accruals, a rate that is virtually identical to our overall patient population and indicates no bias or difficulty enterig minorities onto clinical trials. The MMC MBCCOP therefore has thus been successful to enter minority subjects in proportion to their prevalence in our medical center. It has been recently noted that Hispanic patients are; increasingly seeking care at the NGH and are beginning to be entered onto clinical trials. Women are entered onto all trials in proportion to their disease prevalence with substantially greater numbers entered onto breast cancer and GOG trials compared to men. Historically, 60% of our patients entered onto clinical trials were women which is a skewed rate based on the most active trials treating breast cancer. During the reporting period of this application, the prevalence of African-Americans evaluated entered onto clinical trials at the NGH and the percentage of women on all clinical trials for all research protocols was similar to our summary trends. In addition to the clinical trial efforts, the MBCCOP has leveraged other funds to establish a 1)Hematology/Oncology fellowship opportunity for minority physicians and 2) a peer-reviewed funded research effort in cancer issues of the underserved that includes national presentations and a recently awarded P20 project studying post-treatment "survivorship" of the underserved.