FASEB SRC on AMP-activated protein kinase

说明(申请人提供)：AMPK是一种应激信号转导酶，可磷酸化调节细胞新陈代谢、生长和增殖、离子通道活性以及基本细胞过程的关键蛋白质，包括线粒体生物发生、自噬、内质网应激和细胞凋亡。AMPK在心血管疾病、糖尿病/肥胖症和癌症中有新的重要作用。它在对缺血、心肌肥大、心力衰竭、血管生成和动脉粥样硬化的反应中起着关键作用。AMPK领域正在以非常快的速度向前发展，从理解调节该激酶的新机制、其基本生物学作用以及其在人类疾病的发病机制和治疗中的潜在作用的角度来看。本申请的目的是请求NIH支持将于2012年10月7-12日在加利福尼亚州太平洋格罗夫斯的Asilomar会议中心举行的关于AMPK的2012年FASE B夏季会议，该会议的标题是“AMPK及其以后：生物行动、病理生理学和治疗机会”。这将是第七届AMPK会议，聚集了顶尖的科学家和受训人员，讨论最先进的知识，并为未来的研究开发关键领域。这次会议的目的是促进重要的科学交流和促进富有成效的合作的发展，这些合作将对理解AMPK和AMPK相关的激酶在人类疾病中的作用产生重大影响。自2000年首次会议以来，这次会议引起了极大的科学兴趣，而且随着AMPK在心血管疾病、新陈代谢、衰老和癌症中的关键作用的出现，这种兴趣继续增长。因此，这次会议的总体目的是将最具创新精神的知名研究人员、早期职业科学家和实习生聚集在一起；它将积极招募 女性和少数民族科学家。AMPK领域的许多顶尖科学家都承诺作为大会的特邀演讲者和主席出席会议。主要主题包括：1)AMPK调节的新机制，2)AMPK相关酶的作用，3)AMPK在干细胞生物学中的作用，4)AMPK在细胞生长和存活中的作用，5)AMPK在血管生物学和动脉粥样硬化形成中的作用，6)AMPK在心脏缺血和肥大中的作用，7)AMPK在癌症中的作用，8)AMPK在糖尿病和代谢性疾病中的作用，以及9)AMPK作为药理靶标。这次会议将努力帮助提供一个愿景，即最近的科学进步加上新的治疗策略如何能够推动翻译研究，以发现抗击人类疾病的新策略。 与公共健康相关：AMP激活的蛋白激酶(AMPK)正在成为调节细胞能量、生长和在不利条件下存活的关键酶。AMPK的改变在包括心脏病、糖尿病、肥胖症和癌症在内的许多疾病的发展中发挥着作用。这项申请将有助于资助第七届国际AMPK会议，以促进研究AMPK的科学家之间的互动，包括备受尊敬的知名研究人员和新兴的年轻科学家。预计这次会议上的科学互动和讨论将产生新的想法，导致治疗人类疾病的创新方法。

DESCRIPTION (provided by applicant): AMP-activated protein kinase (AMPK) is a stress signaling enzyme that phosphorylates critical proteins regulating cellular metabolism, growth and proliferation, and ion channel activity, as well as fundamental cellular processes, including mitochondrial biogenesis, autophagy, ER stress and apoptosis. AMPK has emerging important actions in cardiovascular disease, diabetes/obesity and cancer. It has critical roles in the response to ischemia, cardiac hypertrophy, heart failure, angiogenesis and atherosclerosis. The AMPK field is moving forward at a very rapid pace from the perspective of understanding novel mechanisms regulating the kinase, its fundamental biological actions and its potential role in the pathogenesis and treatment of human disease. The purpose of this application is to request NIH support for the 2012 FASEB summer conference on AMPK, which is entitled "AMPK and Beyond: Biological Actions, Pathophysiology and Therapeutic Opportunities," to be held at the Asilomar Conference Center in Pacific Groves, CA on October 7-12, 2012. This will be the 7th biannual AMPK meeting, bringing together leading scientists and trainees to discuss state-of-the art knowledge and to develop key areas for future research. The aim of the conference is to promote important scientific exchange and facilitate the development of productive collaborations that will have a substantial impact on understanding the role of AMPK and the AMPK-related kinases in human disease. The conference has garnered a great deal of scientific interest since its original meeting in 2000, and this interest continues to grow as the essential role of AMPK in cardiovascular disease, metabolism, aging, and cancer is emerging. Thus, the over-arching purpose of this conference is to bring together the most innovative established investigators, early career scientists, and trainees; it will actively recruit the participation of women and minority scientists. Many of the leading scientists in the AMPK field have made commitments to attend as invited speakers and chairs for the conference. Major themes will include: 1) novel mechanisms of AMPK regulation, 2) actions of AMPK-related kinases 3) AMPK in stem cell biology, 4) AMPK in cell growth and survival 5) AMPK in vascular biology and atherogenesis, 6) AMPK in cardiac ischemia and hypertrophy, 7) AMPK in cancer, 8) AMPK in diabetes and metabolic disease, and 9) AMPK as a pharmacological target. The conference will strive to help provide a vision for how recent scientific advancements coupled with new therapeutic strategies can move forward translational research to discover novel strategies to combat human disease. PUBLIC HEALTH RELEVANCE: The AMP-activated protein kinase (AMPK) is emerging as a critical enzyme that regulates cellular energy, growth, and survival under adverse conditions. Alterations in AMPK play a role in the development of many diseases including heart disease, diabetes, obesity, and cancer. This application will help to fund the 7th international AMPK conference to promote interaction among the scientists studying AMPK, including highly respected established investigators and emerging young scientists. Scientific interactions and discussions at this meeting are anticipated to generate new ideas, leading to innovative approaches to treat human disease.