14th Annual Midwest DNA Repair Symposium

描述(由申请人提供)：本提案的总体目标是获得资金，以支持将于2012年5月19-20日在俄亥俄州辛辛那提大学举行的第14届中西部DNA修复研讨会(AMDRS)，辛辛那提儿童医院医学中心(CCHMC)是联合主办单位。AMDRS是一个地区性会议，聚集了来自中西部的研究人员，他们研究DNA损伤/修复及其与癌症的关系。DNA修复途径是维持基因组稳定性所必需的，而修复途径的缺失会导致基因组突变和肿瘤的发生。DNA修复和修复途径的调节也会影响化疗药物的疗效。AMDRS拥有高质量的科学项目，但价格实惠且方便。因此，它吸引了来自中西部各地的各种研究人员。它为学生、博士后研究员和年轻的私人投资人员介绍他们的工作和与高级调查人员互动提供了一个极好的机会。高级私人投资总监喜欢它，因为它的科学质量和与邻近机构的同事互动的独特机会。它还吸引了那些 对DNA损伤/修复感兴趣，但在外围地区工作，通常不会参加全国性DNA修复会议。该计划将包括著名科学家的主题演讲，四次简短的演讲和两次海报会议。重点将放在与DNA损伤/修复与癌症发展、检测和治疗之间的交集相关的新技术/方法上。会议的目的是：为主要来自中西部各州的DNA修复研究人员提供一个场所，介绍他们研究计划的最新进展，与其他研究人员建立网络，并形成新的合作。2.为研究生、博士后研究员和青年研究人员提供一个在同行中介绍他们的研究并与该领域的领导人互动的场所。3.提供一个负担得起但高质量的科学会议，允许DNA修复社区的不同成员参加。 公共卫生相关性：这项提案寻求资金支持一次区域会议，重点是DNA修复及其与癌症发展、检测和治疗的相关性。这次会议将吸引来自中西部的不同研究人员，因此将有助于传播信息，这些信息将增强我们对DNA损伤/修复和肿瘤发生之间的关系以及如何将这种关系用于癌症诊断和治疗的理解。

DESCRIPTION (provided by applicant): The overall objective of this proposal is to secure funding to support the 14th Annual Midwest DNA repair Symposium (AMDRS) to be held May 19-20, 2012 at the University of Cincinnati, Cincinnati, OH, with Cincinnati Children's Hospital Medical Center (CCHMC) as co-host. AMDRS is a regional conference that brings together researchers from across the Midwest who study DNA damage/repair and how it relates to cancer. DNA repair pathways are required to maintain genomic stability with loss of repair pathways leading to genomic mutations and tumorigenesis. DNA repair and regulation of repair pathways can also influence the effect of chemotherapeutic agents. The AMDRS has a high quality scientific program but is affordable and convenient. Consequently, it attracts a diverse array of researchers from across the Midwest. It provides an excellent opportunity for students, post-doctoral fellows and young PIs to present their work and to interact with senior investigators. It is enjoyed by senior PIs because of the scientific quality and the unique opportunity to interact with colleagues from neighboring institutions. It also attracts PIs who are interested in DNA damage/repair but who work in peripheral areas and would not normally attend a national DNA repair meeting. The program will include keynote lectures from prominent scientists, four sessions of short talks and two poster sessions. There will be a focus on new technology/approaches relevant to the intersection between DNA damage/repair and cancer development, detection and treatment. The aims of the conference are: To provide a venue for DNA repair researchers, principally from the Midwestern states, to present recent progress in their research programs, to network with other investigators and to form new collaborations. 2. To provide a venue for graduate students, postdoctoral fellows and young investigators to present their research among peers and to interact with leaders in the field. 3. To provide an affordable but high quality scientific meeting that allows participation from the diverse constituents of the DNA repair community. PUBLIC HEALTH RELEVANCE: This proposal seeks funding to support a regional conference focusing on DNA repair and its relevance to cancer development, detection and treatment. The conference will attract a diverse group of researchers from across the Midwest and hence will help disseminate information that will enhance our understanding of the relationship between DNA damage/repair and tumorigenesis and how this relationship can be exploited in cancer diagnosis and treatment.