Adminstrative Core

项目总结(见说明)： 这份哈佛大学范围内的抗生素耐药性计划(HPAR)提案概述了一种新型、跨学科、合作伙伴关系的设计和功能，以开发和测试新的有效先导化合物，以改变耐多药MRSA、VRE和现在的VRSA感染的治疗模式。虽然发现新的和有希望的新化合物并将其交付到开发流水线是一个主要的总体目标，因为这是一项学术努力，增加了支撑这些病原体抑制剂开发的科学知识基础；了解耐药性，以及开发用于研究宿主-病原体相互作用和多重耐药病原体的新工具也是主要目标。 该项目是由一群经验丰富的科学家提出的，他们在细胞壁生物合成的生物化学和利用这些信息设计筛子和新的抑制剂；模型宿主系统的分子生物学和以新的方式使用这些系统筛选阻止细菌伤害宿主的化合物；模型系统中生物膜形成的生物学和分子遗传学以及利用这些信息识别生物膜破坏剂；肠球菌的发病机制、遗传学和抗生素耐药性；以及多重耐药葡萄球菌感染的发病机制、分子生物学和临床治疗。这些科学专业知识还包括管理经验，包括担任大学负责研究的副校长和研究机构的总裁兼首席执行官。HPAR管理核心的目标是创建一个具有凝聚力且运行良好的整体，该整体大于单个项目的总和。管理核心的具体目标是：1)提供项目管理和监督；2)促进哈佛大学不同部门参与者之间的互动；3)为项目的财务管理提供关键的基础设施；4)提供与哈佛范围内的其他倡议的联系和利用；5)为与NIAID和项目官员以及其他NIAID倡议的持续沟通提供单点联系和积极协调。

PROJECT SUMMARY (See instructions): This Harvard-wide Program on Antibiotic Resistance (HPAR) proposal outlines the design and function of a novel, interdisciplinary, collaborative partnership to develop and test new validated lead compounds for changing the paradigms for treatment of multidrug resistant MRSA, VRE and now VRSA infections. Although discovery and delivery of novel and promising new compounds to the development pipeline is a major overall goal, because this is an academic effort, adding to the base of scientific knowledge that underpins the development of inhibitors for these pathogens; the understanding of resistance, and development of novel new tools for studying host-pathogen interactions and multidrug resistant pathogens are also major goals. This project is being proposed by an accomplished group of scientists with extensive experience in the biochemistry of cell wall biosynthesis and use of that information to design screens and new inhibitors; the molecular biology of model host systems and the use of those systems in novel ways for screening compounds that block the ability of bacteria to harm the host; the biology and molecular genetics of biofilm formation in model systems and the use of that information to identify biofilm disrupting agents; the pathogenesis, genetics and antibiotic resistance of enterococci; and the pathogenesis, molecular biology and clinical treatment of infection caused by multidrug resistant staphylococci. This scientific expertise is complemented by administrative experience that includes service as university Vice President for Research, and President and CEO of a research institute. The goal of the HPAR Administrative Core is to create a cohesive and well functioning whole that is greater than the sum of the individual projects. The Specific Aims of the Administrative Core are to 1) Provide program management and oversight, 2) Facilitate interactions between participants from the various components of Harvard University, 3) Provide critical infrastructure for fiscal management of the program; 4) Provide connectivity to and leverage from other Harvard-wide initiatives; and 5) Provide a single point of contact and active coordination for on-going communication with NIAID and the Program Officer, and other NIAID initiatives.