Tissue Bank

组织库（核心C）提供了基础设施，可将骨髓增生性肿瘤（MPN）患者的标本提供给进行转化研究的研究人员，以便为MPN患者开发创新疗法。组织库的功能是：1）获取MPN组织，2）作为MPN组织的储存库，3）分发MPN组织用于研究，以及4）通过将组织分发到核心实验室来促进生物标志物测定的执行。MPD研究联盟（MPD-RC）的成员和整个科学界都可以使用组织进行转化研究。核心C是一个必不可少的共享资源，使转化研究，将导致改善诊断和分期的MPN，并最终导致分子靶向治疗的发展。组织库核心C的具体目标是：1）根据标准操作规程（SOP），以有效、有组织的方式接收、处理、冷冻保存和储存来自MPD-RC临床研究中心诊断的MPN患者的组织。 2)为MPN组织提供一个中央存储库，该存储库与生物统计和数据管理核心B维护的基于网络的数据库中存储的基本数据相关。这些基本数据包括临床、实验室和家族人口统计学数据，这些数据可以选择和分配最适合每个转化研究项目的组织。3)使MPD联盟的研究人员和科学界能够随时获得冷冻保存的组织，用于研究。4)通过接收、处理、冷冻保存和储存来自MPN患者的组织，并将这些组织分发给联盟生物标志物测定实验室，促进旨在预测疾病进展、血栓并发症和治疗反应的生物标志物测定的执行。这些组织是在诊断时和项目6中描述的个体方案中指定的时间间隔从患者中采集的。生物标志物测定提供了预期与临床试验终点相关的数据。来自600多名患者的标本目前储存在核心C中。超过275名患者的组织已分发给MPD-RC和整个科学界的成员进行研究。

The Tissue Bank (Core C) provides the infrastructure to provide specimens from patients with myeloproliferative neoplasms (MPN) to investigators performing translational research for the purpose of developing innovative therapies for MPN pafients. The functions of the tissue bank are to: 1) acquire MPN tissues, 2) act as a repository for MPN tissues, 3) distribute MPN fissues for research, and 4) facilitate the performance of biomarker assays by distributing tissues to core laboratories. Tissues are available to members of the MPD Research Consortium (MPD-RC) and to the scientific community at large for the performance of translational research. Core C is an essential shared resource that enables translational research that will result in improved diagnosis and staging of MPN and ultimately lead to the development of molecularly targeted therapies. The specific aims of Tissue Bank Core C are to: 1) Receive, process, cryopreserve, and store tissues from MPN patients diagnosed at MPD-RC clinical sites in an efficient, organized manner according to standard operafing procedures (SOPs). 2) Provide a central repository for MPN tissues that are associated with basic data stored in the web-based data bank maintained by Biostatistics and Data Management Core B. These basic data include clinical, laboratory and familial demographic data that enable selection and distribution of tissues best suited for each translational research project. 3) Make the cryopreseved tissues readily available to the MPD Consortium investigators and scientific community at large for research studies. 4) Facilitate the performance of biomarker assays designed to predict disease progression, thrombofic complications, and therapeutic response, by receiving, processing, cryopreserving, and storing tissues from MPN patients, and distributing these tissues to consortium biomarker assay labs. These tissues are collected from patients at diagnosis and at intervals designated in individual protocols described in Project 6. Biomarker assays provide data that are anticipated to correlate with clinical trial endpoints. Specimens from more than 600 patients are cun-ently banked in Core C. Tissues from more than 275 patients have been distributed for research to members of the MPD-RC and the scientific community at large.