Protective T cell responses to Chlamydial Infection

盆腔炎性疾病定义为子宫内膜、输卵管及邻近部位的感染。 由微生物从下生殖道上升到上生殖道所引起的结构 最能令人信服地与产后应激障碍相关的微生物是沙眼衣原体，我们的建议是 为发现抗原特异的细胞介导的免疫应答提供了令人兴奋的机会 与预防沙眼衣原体感染以及阐明沙眼衣原体抗原密切相关 特异性免疫反应与控制沙眼衣原体感染到下生殖道有关。这个 参加这项纵向调查的200名妇女将从急性产后应激障碍队列中招募(项目1) 来自一组有宫颈沙眼衣原体感染高危人群的妇女(项目4)。 我们的调查完成后，将允许： 1.更好地了解与以下方面最相关的CD4T细胞抗原特异性反应 在入学时防止沙眼衣原体感染。 2.更好地阐明与以下因素最相关的CD4T细胞抗原特异性反应 预防沙眼衣原体感染。 3.鉴定与衣原体感染最相关的新的衣原体特异性T细胞反应。 沙眼衣原体从下生殖道上升到上生殖道的可能性降低。

Pelvic inflammatory disease (PID) is defined as an infection of the endometrium, fallopian tubes, and adjacent structures that is caused by the ascension of microorganisms from the lower to upper genital tract The microorganism most convincingly associated with PID is Chlamydia trachomatis, and our proposal would provide the exciting opportinity for a discovery of the antigen-specific cell mediated immune resposes that are most strongly associated with protection against C. trachomatis infection as well as the elucidation of the antigen specifc immune responses correlated with containment of C. trachomatis infection to the lower genital tract. The 200 women enrolled into this longitudinal investigation will be recruited from an acute PID cohort (Project 1) and from a cohort of women who are at high risk for endocervical infection with C. trachomatis (Project 4). Completion of our investigation will allow: 1. Better understanding of the CD4 T cell antigen-specific responses that are most strongly associated with protection from C. trachomatis infection at enrollment. 2. Better elucidation of the CD4 T cell antigen-specific responses that are most strongly correlated with protection from incident C. trachomatis infection. 3. Identification of novel chlamydia-specific T cell responses that are most strongly associated with the decreased likelihood of ascension of C. trachomatis from the lower to upper genital tract.