EXPERIMENTAL IRRADITOR

共享资源描述 自1986年以来一直存在的实验辐射器核心，维护和操作电离辐射源，供西德尼·基梅尔综合癌症中心成员在其实验研究中使用。资源工作人员提供的服务包括辐射源操作培训、就使用辐射的实验设计向用户提供咨询意见、安排辐射源的使用、在必要时操作辐射源、新实验装置的剂量测定以及资源的维护和修理。当会员不使用这些设施时，非会员也可以在增加费用的基础上使用这些设施。该设施的主要资源是五台铯-137辐照器和一台图像引导正电压X射线管辐照器。两个Nordion Gammacell 40内照射器主要用于啮齿动物的全身照射或以恒定剂量率照射附着的培养细胞。Shepherd Mark I辐照器主要用于向动物肿瘤或其他部分身体辐照提供辐射，剂量率与外部射束放射治疗中使用的剂量率相当。然而，该辐照器可以以宽范围的剂量率递送辐射以用于各种目的，诸如细胞悬浮液的辐照或高剂量的辐照以灭菌植入材料。Gammacell 1000辐照器用于以恒定剂量率辐照悬浮培养物。低剂量率辐照器，内置的Shepherd 81源，主要用于辐照细胞培养物的剂量率与肿瘤治疗中使用的放射性植入物相当，但可以提供辐射在任何低于2戈伊/小时的速度，也被用于研究长期暴露于低剂量率辐射致癌。一个内部构建的图像引导小动物辐射研究平台（SARRP）现在可用于核心机构，位于大卫科赫癌症研究大楼（CRBll）。SARRP设计用于在动物模型中产生与目前在人类患者中可实现的相同程度的剂量递送精度。Lay The Experimental Irradiator Core允许研究人员向各种生物材料和活体动物提供特定剂量的辐射。根据研究人员的实验设计，这些仪器可以照射血液制品，动物的全身或将辐射束直接照射到小鼠的小肿瘤上。 SKCCC托管共享资源 当前资助年度报告期：2010年1月1日至2010年12月31日

DESCRIPTION OF SHARED RESOURCE The Experimental Irradiator Core, which has been in existence since 1986, maintains and operates sources of ionizing radiation for use by Sidney Kimmel Comprehensive Cancer Center (SKCCC) members in their experimental studies. Services performed by the resource staff include training in the operation of the sources, advice to users on the design of experiments using radiation, scheduling use of the sources, operating the sources when necessary, dosimetry for new experimental setups, and maintenance and repair of the resources. When not in use by members, these facilities are also available to non-members on an increased-fee basis. The primary resources of the facility are five Cs-137 irradiators and one image guided orthovoltage x-ray tube irradiator (SARRP). Two Nordion Gammacell 40 in-adiators are primarily used for whole body irradiation of rodents or irradiation of attached cultured cells at a constant dose rate. The Shepherd Mark I irradiator is used primarily to deliver radiation to animal tumors or other partial-body irradiations at dose rates comparable to those used in external beam radiotherapy. However, this irradiator can deliver radiation at a broad range of dose rates for a variety of purposes, such as irradiation of cell suspensions or irradiation to high doses to sterilize implant material. The Gammacell 1000 irradiator is used to irradiate suspension cultures at a constant dose rate. The low-dose-rate irradiator, built in-house with a Shepherd 81 source, is used primarily to irradiate cell cultures at dose rates comparable to those used in tumor therapy with radioactive implants, but can deliver radiation at any rate below two Gy/hr and has also been used in studies of carcinogenesis from prolonged exposure to low-dose-rate radiation. An in-house built image-guided small animal radiation research platform (SARRP) is now available to the Core facility and is located in the David Koch Cancer Research Building (CRBll). The SARRP is designed to produce the same degree of dose delivery precision in animal models as is currently achievable in human patients. Lay The Experimental Irradiator Core allows researchers to deliver specific doses of radiation to a wide range of biological materials and live animals. Depending on a researcher's experimental design, these instruments can irradiate blood products, whole bodies of animals or direct a radiation beam to a small tumor on a mouse. SKCCC Managed Shared Resource Current Grant Year Reporting Period: January 1, 2010 to December 31, 2010