CLINICAL TRIAL: THE EFFECT OF VITAMIN D SUPPLEMENTATION ON PRE-DIABETES IN A MIN

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 心血管疾病（CVD）和相关疾病仍然是美国死亡的主要原因，糖尿病与CVD密切相关。非裔美国人、西班牙裔/拉丁裔美国人、美洲印第安人、阿拉斯加原住民、一些亚裔美国人、夏威夷原住民和其他太平洋岛民患2型糖尿病的风险特别高。少数民族和种族的糖尿病发病率目前正在增加（1），预计将继续以惊人的速度增加（2）。尽管获得医疗服务或遗传变异可能起作用，但有助于解释这种健康差异的有趣生物学解释是维生素D水平的种族差异。少数种族/民族血清25-羟基维生素D（925-OHD）水平降低，非洲裔美国人的水平低于白人，西班牙裔/拉丁裔美国人的水平居中（3-5）。少数种族/民族的血清25-OHD水平较低可能是由于皮肤色素沉着增加，尽管阳光照射减少、饮食中维生素D摄入量减少或其他因素也可能起作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular disease (CVD) and related disorders remain the leading cause of death in the nation and diabetes in strongly linked to CVD. African-Americans, Hispanic/Latino Americans, American Indians, Alaska Natives, some Asian-Americans, Native Hawaiians and other Pacific Islanders, are at particularly high risk for the development o type 2 diabetes. Rates of diabetes in ethnic and racial minorities are presently increased (1) and are projected to continue to increase at an alarming rate (2). Although access to medical care or genetic variations may have a role, an intriguing biological explanation to help explain this health disparity is racial differences in vitamin Dlevels. Racial/ethnic minorities have reduced serum 25-hydroxy vitamin D 925-OHD) levels, with African-Americans having lower levels than Caucasians and Hispanic/Latino Americans having intermediate levels (3-5). The low serum 25-OHD levels in racial/ethnic minorities may be due to increased skin pigmentation, although reduced sun exposure, reduced dietary intake of vitamin D or other factor may also play a role.