Sickle Cell Scholar Component

这位学者将在鲁班博士的领导下，将至少75%的精力用于镰状细胞性贫血相关的研究。鲁班博士是一名知名的临床研究员，也是CNMC的教员培训和指导工作的负责人。鲁班博士将与WACSCC的医生和科学家一起制定一项精心规划的个性化研究培训计划，旨在确保学者成为一名专注于与镰状细胞疾病相关的关键翻译和临床问题的独立医生和/或生物医学研究人员。将为Sickle Cell学者制定个性化的职业发展计划(ICDP)(附录A)，该计划将包括三个主要组成部分：核心课程、实验室培训和临床环境中的翻译应用。 第一部分是正式的课程作业，包括各种学科：统计学、流行病学、临床试验设计、临床调查的监管方面、研究伦理、临床调查的科学工具、临床调查中的分析技术，以及生物化学、分子生物学的原理和技术。 和分子遗传学。这些课程将通过HU(RR010284)和CNMC(RR020359)临床研究中心和HU研究科学家计划(R25HL003679)提供，并由我们联合 K30和相关的T32和K12计划，以及通过在HUSM和CNMC、当地大学和NIH选定的计划进行的课程工作 第二个组成部分提供高度结构化的实验室培训计划，旨在提供生物化学、分子生物学、遗传学和分析技术方面的实践培训，以及在WACSCC协作实验室和GCRC实施的试验台调查和临床调查所产生的临床和实验室数据分析方面的培训。内科科学家与流行病学 对医疗保健差异和护理提供感兴趣的研究人员将参与旨在学习基于数据的调查和定量研究的方法论方法的项目。 第三部分包括开发和实施镰状细胞病的临床项目。 该学者将设计、实施并参与指导临床研究项目的实施。学者培训的这一部分将确保他/她发展进行多学科临床研究所需的培训，认识到此类研究中的困难，并开发工具，以确保未来作为临床研究人员或合作生物医学研究人员的成功。 镰刀细胞学者计划的最终目标是激励年轻和/或新的研究人员将他们的职业生涯献给创新和富有成效的研究，以减少这种疾病的负担和污点。

The Scholar will spend at least 75 percent of his/her effort in sickle cell anemia-related research under the leadership of Dr. Luban, an established clinical investigator who also directs faculty training and mentorship at CNMC. Dr. Luban in conjunction with the physicians and scientist of WACSCC will develop a carefully planned, individualized research training program designed to ensure that the Scholar becomes an independent physician and/or biomedical researcher focused on critical translational and clinical questions related to sickle cell disease. An individualized career development plan (ICDP) (Appendix A) will be developed for the Sickle Cell Scholar and will encompass three major components: core curriculum, laboratory training and translational applications in the clinical setting. The first component is formal course work including a variety of disciplines: statistics, epidemiology, clinical trial design, regulatory aspects of clinical investigation, research ethics, scientific tools of clinical investigation, analytical techniques in clinical investigation, and principles and techniques of biochemistry, molecular biology and molecular genetics. These courses will be provided through the HU (RR010284) and CNMC (RR020359) Clinical Research Centers and the HU Research Scientist Program (R25HL003679) augmented by our joint K30 and associated T32 and K12 programs and by course work at HUSM and CNMC, local universities and through selected programs at NIH The second component provides a highly structured laboratory training program that is designed to provide practical training in biochemistry, molecular biology, genetics and analytic techniques, and in the analysis of clinical and laboratory data that results from bench investigations and clinical investigation implemented at the WACSCC collaborative laboratories and GCRCs. Physician scientists and epidemiologic researchers with interests in health care disparities and care delivery will engage in programs designed to learn methodological approaches to data- based investigations and quantitative research. The third component consists of developing and conducting a clinical project in sickle cell disease. The scholar will design, implement and participate in the conduct of a mentored clinical research project. This part of Scholar's training will ensure that he/she develops the training needed to conduct multidisciplinary clinical research, recognize the difficulties in such studies and develop tools to ensure future success as a clinical researcher or collaborative biomedical researcher. The ultimate goal of the Sickle Cell Scholar program is to inspire young and/or new investigators to devote their career to innovative and productive research that will lead to decreasing the disease burden and stigmata of this disease.