ODF: Support infrastructure for NextGen sequence storage analysis and mgt

描述（由申请人提供）：开放科学数据框架（OSDF）将提供在联合云支持的数据和计算环境中进行生物信息学分析所需的架构和软件。OSDF由一个数据存储和数据交换程序组成，具有一个应用程序接口（API），以支持用户社区的数据提交、检索和分析。OSDF将支持各种用户，包括（1）需要存储和处理原始数据的序列生成器（2）需要访问参考数据集的工具和管道开发人员，以及（3）需要实时查询参考数据的基于Web的资源。基因组学社区将能够使用此资源来处理人类基因组、转录组和宏基因组数据，以进行分析，包括人类变异检测、转录组分析、表观遗传分析和微生物组分析。为了实现这些目标，我们建议：1）建立OSDF软件栈; 2）通过将OSDF与启用云的虚拟机中已建立的社区支持管道集成，确保此数据的可用性; 3）创建两个OSDF数据库，我们将在其中托管来自1000个基因组计划MG-RAST的公开可用的基因组、转录组和宏基因组数据，和人类微生物组项目以及一些中间和最终分析结果; 4）向用户社区提供使用该系统的适当文件和培训。

DESCRIPTION (provided by applicant): The Open Science Data Framework (OSDF) will provide the architecture and software necessary for conducting bioinformatics analyses in a federated cloud-enabled data and computational environment. The OSDF consists of a data store and data exchange procedures with an Application Program Interface (API) to support data submissions, retrievals and analysis for the user community. OSDF will support a diverse set of users, including (1) sequence generators that need to store and process raw data (2) tool and pipeline developers that need access to reference data sets, and (3) web-based resources that need real-time querying of reference data. The genomics community will be able to use this resource to process human genomic, transcriptomics, and metagenomic data to conduct analyses that include human variation detection, transcriptome analysis, epigenetic analysis, and microbiome analysis. To accomplish these goals we propose to: 1) establish the OSDF software stack and; 2) ensure the usability of this data by integrating OSDF with established community supported pipelines in Cloud-enabled virtual machines; 3) create two OSDF Instances where we will host publicly available genomic, transcriptomics, and metagenomic data from the 1000 Genomes Project, MG-RAST, and Human Microbiome Project and some of the intermediate and final analysis results; 4) provide adequate documentation and training to the user community to use the system.