P30 - Core Grant for Vision Research

描述（由申请人提供）：继续支持要求在埃默里大学和邻近的亚特兰大机构的视觉研究的NEI核心补助金。该核心中心资助更新申请包括三个模块：（1）结构生物学和成像，（2）功能基因组学和蛋白质组学，以及（3）生物信息学和生物统计学。过去的核心补助金支持42名教师（包括31名NEI资助的主要研究者的36个单独奖项），16名博士后研究员，6名博士前研究员之间的合作视觉研究和服务，并在过去5年中产生了500多篇同行评议的出版物。结构生物学和成像模块在此更新中增加了对免疫组织化学，共聚焦显微镜，荧光图像分析以及光学和电子显微镜服务的现有支持的超声检查。功能基因组学和蛋白质组学模块为啮齿类动物的视觉表型分析增加了新的功能，包括SD-OCT、扫描激光检眼镜、部分相干干涉测量、高精度显微测量、摄影验光、前房角镜检查、回弹眼压测量、ERG和OKT， 寡核苷酸合成、HPLC分析、质谱法、PCR、激光捕获显微切割、基因和蛋白质测序以及微阵列分析。生物信息学和生物统计学模块提供生物统计学、生物信息学、数据管理、电子笔记本、数据备份和高级计算分析。核心由方案主任和每个单元的一两名单元主任管理;核心赠款咨询委员会将协助单元主任确保设施得到充分和公平的利用，并就根据需要创造新资源或消除利用不足的组成部分提出建议。核心单元已经并将继续通过提供共同的集中服务来提高研究生产力，以刺激和促进教师之间的合作研究，并吸引其他学科进行视觉研究。

DESCRIPTION (provided by applicant): Continued support is requested forth NEI Core Grant for Vision Research at Emory University and neighboring Atlanta institutions. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past core grant supported collaborative vision research and service among 42 faculty (including 36 separate awards by 31 NEI funded principal investigators),16 postdoctoral fellows, 6 predoctoral fellows and generated 500+ peer-reviewed publications in the past 5 years. The Structural Biology and Imaging Module adds ultrasonography in this renewal to existing support for immunohistochemistry, confocal microscopy, fluorescence image analysis, and light and electron microscopy services. The Functional Genomics and Proteomics module adds new capabilities for visual phenotyping of rodents, including SD-OCT, scanning laser ophthalmoscopy, partial coherence interferometry, high precision micrometry, photorefraction, gonioscopy, rebound tonometry, ERG, and OKT, to pre-existing services for oligonucleotide synthesis, HPLC analyses, mass spectrometry, PCR, laser capture microdissection, gene and protein sequencing, and microarray analysis. The Bioinformatics and Biostatistics Module provides biostatistics, bioinformatics, data management, electronic notebooks, data backups, and advanced computational analyses. The Core is administered by the Program Director and one-two Module Directors for each of the Modules; a Core Grant Advisory Committee will aid the module directors to insure full and equitable use of the facilities and to advise on creation of new resources based on need or eliminate components that are underutilized. The Core Modules have and will continue to increase research productivity by providing common centralized services to stimulate and facilitate collaborative studies among faculty and to attract other academic disciplines to vision research.