Hispanic Community Children???s Health Study of Latino Youth SOL-Youth

描述（由申请人提供）：儿童时期的超重和肥胖严重影响成年后心血管疾病和糖尿病的风险。本研究将是第一个关于生活在美国的西班牙裔儿童（8-14岁）超重、肥胖和心脏代谢危险因素的全国性研究。具体目的：(1)评估青少年文化适应的影响以及青少年与父母之间文化适应的代际差异对青少年生活方式行为和心脏代谢风险概况的影响；(2)检验父母教养策略和做法与儿童生活方式行为和心脏代谢风险概况的关系；(3)评估青少年心理社会功能对青少年生活方式行为和心脏代谢风险概况的影响。研究设计：来自五所大学的研究人员将招募1,600名年龄在8至14岁之间的男孩和女孩，至少有一位父母参加西班牙裔社区健康研究（HCHS/拉丁裔健康研究（SOL））。SOL是一项针对16000名西班牙裔/拉丁裔成年人（18-74岁）的多中心流行病学研究，旨在确定文化适应在心血管疾病和糖尿病的流行和发展中的作用，并确定在决定西班牙裔/拉丁裔成年人健康方面发挥保护或有害作用的风险因素。数据收集：拟议的SOL儿童研究（SOL- youth）的参与者将接受一个3小时的临床检查和7天的身体活动监测。在临床检查期间，青少年将完成一份由访谈者管理的问卷，评估文化适应、青春期发育、心理功能、身体活动、饮食和家庭膳食模式。本研究将进行一个子研究以验证被试自我报告的青春期状态。诊所工作人员将收集青少年的人体测量、血压和血脂数据，参与者将完成有氧体能测试。新的生物标志物的数据，包括内皮功能障碍、炎症和脂肪细胞因子的测量，也将获得。参与青年父母的数据将主要从成人HCHS/SOL研究收集的现有数据中获得，并结合从父母那里获得的关于其子女病史和养育策略的新数据，以促进健康的家庭环境。分析：协调中心的统计学家将分析中央存储的数据，这些数据来自于对文化适应措施与我们感兴趣的主要结果（心脏代谢危险因素和生活方式行为）之间关系的双变量分析，以及使用回归技术的多变量分析。意义：关于风险和保护因素的详细父母和儿童数据将为制定预防和干预计划提供基础，以改善西班牙裔/拉丁裔儿童从童年中期到成年早期的健康状况。研究结果将通过期刊文章、会议报告和媒体传播给专业人士和非专业人士。一个有限使用的数据集也将公开发布。

DESCRIPTION (provided by applicant): Overweight and obesity during childhood strongly influence the risk of cardiovascular diseases and diabetes in adulthood. This study will be the first national study of overweight, obesity and cardiometabolic risk factors among Hispanic children (ages 8-14) living in the U.S. Specific Aims: (1) Evaluate the influence of youth acculturation and intergenerational differences in acculturation between youth and parents on youth's lifestyle behaviors and their cardiometabolic risk profiles; (2) Test the association of parenting strategies and practices with children's lifestyle behaviors and cardiometabolic risk profiles; and, (3) Assess the influence of youths' psychosocial functioning on youth lifestyle behaviors and cardiometabolic risk profiles. Research Design: Researchers from five universities will recruit a sample of 1,600 boys and girls ages 8 to 14 with at least one parent participating in the Hispanic Community Health Study (HCHS/Study of Latino Health (SOL). SOL is a multi-center epidemiologic study of 16,000 Hispanic/Latino adults (ages 18-74) designed to determine the role of acculturation in the prevalence and development of cardiovascular diseases and diabetes, and to identify risk factors playing a protective or harmful role in determining the health of Hispanics/Latino adults. Data Collection: Participants in the proposed SOL Children's Study (SOL-Youth) will undergo a single 3-hour clinical examination and seven days of physical activity monitoring. During the clinical examination, youth will complete an interviewer-administered questionnaire assessing acculturation, pubertal development, psychological functioning, physical activity, diet, and family meal patterns. A substudy will be conducted to provide validation of participants' self reports of pubertal status. Clinic staff will collect anthropometric, blood pressure, and blood lipid data from youth and participants will complete an aerobic fitness test. Data on novel biomarkers, including measures of endothelial dysfunction, inflammation, and adipocytokines, will also be obtained. Data on the parents of participating youth will be obtained primarily from existing data collected by the adult HCHS/SOL study, combined with new data obtained from parents on their children's medical histories and parenting strategies to promote a healthy home environment. Analyses: Statisticians at the coordinating center will analyze centrally stored data proceeding from bivariate analyses of the relationship between acculturation measures and our primary outcomes of interest - cardiometabolic risk factors and life style behaviors - to multivariate analyses using regression techniques. Implications: Detailed parent and child data on risk and protective factors will provide the basis for the development of prevention and intervention programs to improve the health of Hispanic/Latino children from middle childhood to early adulthood. Results will be disseminated to professional and lay communities through journal articles, conference presentations, and the press. A limited use dataset will also be publicly released. PUBLIC HEALTH RELEVANCE: U.S. Latino youth are more overweight or obese than non-Hispanic white youth and are at risk for lasting cardiovascular complications into adulthood. The present study will study a wide range of cultural factors (e.g., family environment, physical, social) associated with obesity in a sample of 1,600 Latino boys and girls aged 8-14 years old from the Bronx, NY; Chicago, IL; Miami, FL and San Diego, CA. Findings from our study will inform practice and policy efforts to develop programs to prevent obesity in Latino youth and thus improve the health of future generations.