UCLA Muscular Dystrophy Core Center

描述（由申请人提供）：加州大学洛杉矶分校肌肉萎缩核心中心由一组对退行性肌肉疾病治疗方法开发感兴趣的科学家组成。该中心的目标是通过提供资源、试点资金和智力丰富的环境来促进研究进展，并鼓励肌肉研究人员与校园内相关学科的其他研究人员之间的富有成效的互动，从而改善和促进肌肉萎缩症的发现和临床前测试过程。该中心的存在将吸引既有肌肉研究人员，也有以前没有进行过肌肉研究的科学家，通过这个协会，将为该小组增加新的专业知识和经验。core将使用基于新型细胞分析和新型转基因小鼠模型的高通量和非侵入性分析。中心科学家使用的高通量和非侵入性策略传统上与肌肉疾病无关，因此可能促进治疗方法的新进展和快速发展。该中心的成员反映了各种不同的科学专业知识，将促进这一努力。行政核心的目的是协调中心的活动并促进实现这些目标。

DESCRIPTION (provided by applicant): The Muscular Dystrophy Core Center at UCLA is comprised of a group of scientists interested in the development of therapeutics for degenerative muscle disease. The goal of the Center is to improve and facilitate the process of discovery and pre-clinical testing for muscular dystrophy by providing resources, pilot funding and an intellectually rich environment that promotes research progress and encourages productive interactions between muscle researchers and other researchers in related disciplines on campus. The existence of the Center will attract scientists that are both established muscle researchers and those that have not previously conducted muscle research and, with this association, add new expertise and experience to the group. The Cores will use high throughput and non-invasive analyses based on novel cellular assays and novel genetically modified mouse models. The high throughput and non-invasive strategies being used by Center Scientists are not traditionally associated with muscle disease and may thereby foster novel advancements and rapid development of therapeutics. The Center membership reflects a variety of different scientific expertise that will facilitate this endeavor. The aims of the Administrative Core are to coordinate the activities of the Center and to facilitate these goals. Specifically the Aims of the Administrative Core are: Aim 1: To provide administrative support to the Cores and all activities of the Center. Aim 2: To facilitate collaboration between Center Scientists and encouragement of Core usage by organizing enrichment activities such as a seminar series, annual retreat and maintenance of a website. Aim 3: To oversee review and funding of pilot and feasibility projects. Aim 4: To facilitate data sharing and use of the cores from the greater community of dystrophy researchers so that the cores will provide a national resource for muscular dystrophy research.