Examining inhibition during spoken word production in aphasia

描述（由申请人提供）：失语症，语言表现障碍，可能部分与注意力下降有关。需要注意促进优先信息的激活和主动抑制干扰信息。据报道，对干扰的感知包括两个部分--兴奋和抑制。对失语症的研究表明，在干扰存在的情况下，语言过程显着减慢。虽然这些结果是至关重要的，但构成干扰控制的两个组成部分-抑制和兴奋-尚未被探索。这项研究将检查失语症成年人与年龄和教育相匹配的对照组在口语产生过程中的抑制作用。将招募40名参与者（20名失语症成年人和20名对照组）参加两组五条件实验，使用Stroop颜色词任务，一种众所周知的干扰测试，嵌入负启动任务，一种广泛接受的抑制措施。将在参与者组内和组间分析所有反应的正确言语反应潜伏期和准确性，以确定与对照组相比失语症患者的抑制程度。这项研究是旨在探索抑制的一系列研究中的第一项， 兴奋，并有助于失语症的工作记忆模型。最终，这一系列的研究将为失语症患者的评估和治疗实践提供信息。 公共卫生相关性：抑制-或抑制分散注意力的信息-是语言过程的一个重要组成部分，但很少有人知道失语症的抑制功能。拟议的研究将检查失语症成人口语单词产生过程中的抑制。这项研究是一系列研究中的第一项，将有助于建立失语症的工作记忆模型，并最终为失语症康复提供新的方法。

DESCRIPTION (provided by applicant): Aphasia, disorder of language performance, may relate in part to diminished attention. Attention is required to both boost activation of priority information and actively inhibit interfering information. Perception of interference reportedly involves two components - excitation and inhibition. Studies of aphasia have shown language processes in the presence of interference are significantly slowed. While these results are critical, the two components which comprise interference control - inhibition and excitation - have yet to be explored. The proposed study will examine inhibition during spoken word production in adults with aphasia compared with age- and education-matched controls. Forty participants - 20 adults with aphasia and 20 controls - will be recruited to participate in a two-group by five-condition experiment using the Stroop color-word task, a well-known test of interference, with an embedded Negative Priming task, a widely accepted measure of inhibition. Correct verbal response latency and accuracy on all responses will be analyzed both within and between participant groups to determine the magnitude of inhibition in people with aphasia compared to controls. This study is the first in a line of research designed to explore inhibition, excitation, and contribute to a working memory model of aphasia. Ultimately, this line of research will inform to assessment and treatment practices for people with aphasia. PUBLIC HEALTH RELEVANCE: Inhibition - or the suppression of distracting information - is an essential part of language processes, yet very little is known about inhibitory function in aphasia The proposed research will examine inhibition during spoken word production in adults with aphasia. This study is the first in a line of research which will contribute to a working memory model of aphasia and ultimately inform new approaches to aphasia rehabilitation.