Clinical Trials Network Mid-Atlantic Collaborative Group

描述（由申请人提供）：中大西洋节点是国家药物滥用治疗临床试验网络的首批参与者之一。它的区域研究和培训中心（RRTC）由约翰霍普金斯大学医学院、弗吉尼亚联邦大学和朋友研究所的杰出教师以及附属社区治疗项目（CTP）的负责人组成。在过去的10年里，研究人员和临床服务提供者之间的这种伙伴关系有效地发挥了作用，并使节点为CTN做出了实质性的贡献，包括领导两项研究，并在过去的5年资助期内参与了7项额外的研究，共有601名受试者入组。重要的是，该节点在出版生产力方面有着出色的记录，有24份出版物报告了CTN的主要研究结果、辅助研究和次要分析，并支持CTN出版物委员会主席。在即将到来的资助期内，Node将与VCU保持合作，同时扩大与Friends研究所的合作关系。这将为节点带来额外的教师专业知识和基础设施支持，包括药物开发（例如Frank Vocci）和刑事司法研究（Timothy Kinlock）方面的专业知识。在弗吉尼亚州立大学，我们与妇女健康研究所（Susan Kornstein）、药物成瘾科学研究所（Robert Balster）和遗传学研究所（Kenneth Kendler）建立了更广泛的联系。在约翰·霍普金斯大学，我们扩大了附属学院，在临床试验、应急管理、认知测试和大麻研究方面引入了更多的专业知识。我们与霍普金斯急诊医学系、马里兰大学牙科学院和约翰霍普金斯临床转化研究所（ICTR）建立了附属关系。最后，我们增加了CTP，包括华盛顿特区的惠特曼沃克诊所，它将初级保健、艾滋病毒护理和共同发生的精神健康障碍纳入其服务范围，以及一个在社区参与性研究方面拥有丰富经验的新诊所（里士满行为健康诊所）。所有这些新的隶属关系将有助于节点满足CTN使命的短期和长期扩展，并参与可能开发的各种各样的研究。最后，该节点将继续开展强有力的传播活动，为附属CTP提供重大利益，同时促进采用循证实践。

DESCRIPTION (provided by applicant): The Mid Atlantic Node was among the first participants in the National Drug Abuse Treatment Clinical Trials Network. It's Regional Research and Training Center (RRTC) is comprised of distinguished faculty from Johns Hopkins University School of Medicine, Virginia Commonwealth University and Friends Research Institute as well as directors of affiliated community treatment programs (CTP's). This partnership between researchers and clinical service providers has been functioning effectively over the past 10 years and has allowed the Node to make substantial contributions to the CTN including leadership of two studies, and participation in 7 additional studies with 601 subjects enrolled during the last 5-year funding period. Importantly, the Node has an outstanding record of publication productivity with 24 publications reporting on CTN main study findings, ancillary studies and secondary analyses and supports the Chair of the CTN Publications Committee. In the upcoming grant period, the Node will maintain collaboration with VCU while expanding its affiliation with Friends Research Institute. This will bring additional faculty expertise and infrastructure support into the Node including expertise in medications development (e.g. Frank Vocci) and criminal justice research (Timothy Kinlock). We have formed broader affiliations at VCU with the Women's Health Institute (Susan Kornstein), the Institute for Drug Addiction Science (Robert Balster) and the Institute for Genetics Research (Kenneth Kendler). At Johns Hopkins, we have expanded faculty affiliates to bring in additional expertise in clinical trials, contingency management, cognitive testing, and marijuana research. We have established affiliations with the Hopkins Department of Emergency Medicine, with the School of Dentistry at University of Maryland and with the Johns Hopkins Institute for Clinical Translational Research (ICTR). Finally, we have added CTP's, including the Whitman Walker Clinic in Washington DC, that incorporate primary care, HIV care and co-occurring mental health disorders in their scope of service and a new clinic (Richmond Behavioral Health) with extensive experience in community participatory research. All these new affiliations will help the Node to meet short- and long-term expansion in the mission of CTN and to participate in a wide variety of studies that are likely to be developed. Finally, the Node will continue its strong dissemination activities that provide significant benefit to affiliated CTP's while promoting adoption of evidence-based practices. PUBLIC HEALTH RELEVANCE: The Mid Atlantic Node is part of a national multi-site clinical trials network supported by the National Institute on Drug Abuse. Mission of the network is to conduct research at community treatment programs that will identify effective therapies for treatment of drug users. Subsequent adoption of new effective treatments by community programs will improve the quality of drug abuse treatment nationwide.