2012 Drug Resistance Gordon Research Conference

描述(由申请人提供)：本申请请求部分资助将于2012年7月29日至8月3日在马萨诸塞州伊斯顿的斯通希尔学院举行的新的戈登耐药性研究会议。这次会议的广泛和长期目标是首次将这一迅速扩大的领域中的世界领先研究人员聚集在一起，促进跨学科的讨论和合作，以加强我们对耐药性演变的理解。这一目标的重点是开发可纳入新药设计的耐药途径和机制的新见解。本次会议的具体目标将是召集40多名涵盖耐药关键领域的领先专家，共有150人参加，在相对孤立的环境中举行为期5天的会议。该计划将分为9个环节，涵盖抗药性挑战、微生物疾病的抗药性、病毒的抗药性、真菌和寄生虫病的抗药性、癌症的抗药性、耐药性的演变、针对抗感染靶标以降低耐药性、新的药物靶标、药物发现以及解决耐药性的多学科方法。此外，下午的海报会议将允许所有参与者为这些主题做出贡献。将尽一切努力鼓励 研究生和博士后，在妇女人数上实现平等，并将少数群体和残疾人包括在内。这一申请的意义在于，这次戈登研究会议将提供有史以来第一个论坛，将致力于抗药性挑战的国际研究界成员聚集在一起并协同工作。这一申请与健康有关的是，所产生的讨论将有助于确定与基础科学有关的重要问题，以及制定药物设计和开发的新战略所需的问题；定义是迫切需要的，以降低与耐药性有关的高死亡率。 与公共卫生相关：耐药性的发生限制了我们许多最有效药物的寿命，从而对数百万患者的生活产生了负面影响。在大多数情况下，耐药性被作为一种疾病特有的努力进行调查，其结果是临床医生和研究人员往往不知道其他疾病的进展、资源和相似之处。本次戈登研究会议对当前研究的讨论将确定需要解决的重要问题，这些问题需要通过利用跨学科和跨疾病的视角来开发新药设计和开发战略，以控制耐药病原体和癌细胞。

DESCRIPTION (provided by applicant): This application requests partial support for a new Gordon Research Conference on Drug Resistance to be held July 29-August 3, 2012 at Stonehill College in Easton, MA. The broad and long-term goal of this conference is to bring together, for the first time, the world's leading researchers in this rapidly expanding field to foter cross-disciplinary discussions and collaborations, so as to enhance our understanding of drug resistance evolution. This goal focuses on the development of new insights on drug resistance pathways and mechanisms that can be incorporated into the design of novel drugs. The specific aims of this meeting will be to convene over 40 leading experts that cover critical areas of drug resistance, with a total of 150 participants for a five-day conference in a relatively isolated setting. The program will be structured into nine sessions covering the drug resistance challenge, resistance in microbial diseases, resistance in viruses, resistance in fungal and parasitic diseases, resistance in cancer, the evolution of resistance, the targeting of anti-infective targets to reduce resistance, novel drug targets, drug discovery, and multi-disciplinary approaches to tackling drug resistance. In addition, afternoon poster sessions will permit all participants to contribute to these topics. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. The significance of this application is that this Gordon Research Conference will provide the first-ever forum for bringing together and synergizing members of the international research community working on the drug resistance challenge. The health relatedness of this application is that the discussions generated will help define the important questions related to both basic science and those required for the development of novel strategies for drug design and development; definitions desperately required so as to reduce the very high levels of mortality associated with drug resistance. PUBLIC HEALTH RELEVANCE: The occurrence of drug resistance negatively impacts the lives of millions of patients by limiting the longevity of many of our most potent drugs. In most cases, drug resistance is investigated as a disease specific endeavor the results of which are that clinicians and researchers are often unaware of the progress, resources, and parallels in other diseases. The discussions of current research at this Gordon Research Conference will define important questions that need to be addressed for the development of new drug design and development strategies for the control of resistant pathogens and cancerous cells by leveraging a cross disciplinary and cross disease perspective.