IRON IN DISEASES OF THE AGEING BRAIN: from bench to clinic
IRON IN DISEASES OF THE AGEING BRAIN: from bench to clinic
批准号:
nhmrc : 1194028
负责人:
金额:
$181.42万
依托单位国家:
澳大利亚
项目类别:
Investigator Grants
财政年份:
2021
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2021-01-01 至 2025-12-31
中文摘要
我的目标是更深入地了解老年无法治愈的神经系统疾病——阿尔茨海默病、帕金森病和运动神经元病的病因、检测和治疗。随着年龄的增长,铁在脑组织中不必要地积累。我将继续研究衰老蠕虫、培养细胞、小鼠、人脑组织、脑成像和临床试验,以确定铁积累问题是否是这些疾病的药物靶点。
英文摘要
I aim to achieve a deeper understanding of the causes, detection and treatment of incurable neurological diseases of advancing age - Alzheimer’s disease, Parkinson’s disease and Motor Neuron Disease. Iron needlessly accumulates in brain tissue with age. I will pursue studies of ageing worms, cells in culture, mice, human brain tissue, brain imaging and clinical trials, to determine whether the problem of iron accumulation is a drug target for these diseases.
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会议论文
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
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批准号:31171277
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项目类别:面上项目
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资助金额:60.0万元
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批准年份:2011
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负责人:Christine Nardini
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依托单位: