How isomiRs expand the microRNA functional repertoire in affecting gene expression

microRNA作为基因表达的调节因子发挥作用。人们逐渐认识到，microRNA经常表达为具有细微不同序列的变体。我们在这里发现，一种重要的癌症相关microRNA miR-222的变异促进了表达它们的细胞行为的差异。这项工作旨在了解microRNA变异如何赋予细胞这些特性，以确定miR-222变体调节的基因，并检查microRNA变异对癌症的影响有多广泛。

MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA variation contributes to cancer.