Core C: Animal Models

核心C(Animal Model Core)的总体目标是支持动物模型的开发和使用 受雇于本计划项目赠款(PPG)。动物模型核心的指导原则是 高效的动物规划和利用，标准化的加工和诊断，可靠的服务 以及对动物模型的一致评估，并成为所有动物成本的成本中心。最基本的 该中心提供的专业知识包括实验动物医学、临床和解剖病理学。这个 CORE设在兽医生物科学系，负责协调工作。Stefan Niewiesk博士建议 Core Director自2004年以来一直担任Animal Core的联席主任，是所有 PPG的首席调查员。他获得了兽医微生物学证书和实验动物证书 医学兽医(欧洲人)。由于Niewiesk博士的独特培训，他还提供了 针对PPG特定项目的单抗和多克隆抗体的产生。托马斯·罗索尔博士 (项目4，Co-Pi)，由美国兽医学院病理学家认证的他将担任联席主任 为了核心。这些调查人员加上经验丰富的技术人员组成了一支经验丰富的 专业的团队来指导核心，满足PPG调查人员的目标。一条共同的主线 所有研究小组都共享使用HTLV-1和HTLV-2独特的传染性分子克隆， 在我们的实验室开发或表征，并链接到已建立的动物模型以测试分子 疾病的决定因素。自2003年以来，调查人员进一步进化出多种新的相互依存的关系 方法、技术和协同交流，用于将他们的科学整合到接近基础的 从项目实验室获得预期成果的生物范例。高度互动的动物核心 由Niewiesk博士指导的将提供一个集中采购和采购的方法，以方便动物 进行研究，减少冗员，促进项目间的协作。一个独特的角色， 动物核心将为教师提供老鼠病理学方面的专业知识，并提供最先进的 方法对骨损伤进行定性和定量。

The overall goal of Core C (Animal Model Core) is to support the development and use of the animal models employed within this Program Project Grant (PPG). The guiding principals for the animal model core are efficient planning and utilization of animals, standardization of processing and diagnoses, reliability of service and consistent evaluation of animal models and being a cost center for all animal costs. The fundamental expertise provided within the core is laboratory animal medicine and clinical and anatomic pathology. The Core is housed and coordinated in the Department of Veterinary Biosciences. Dr. Stefan Niewiesk, proposed Core Director has been co-director of the Animal Core since 2004 and is an active collaborator with all of the principal investigators for the PPG. He is certified in Veterinary Microbiology and as a Laboratory Animal Medicine Veterinarian (European). Because of Dr. Niewiesk's unique training, he also provides expertise in the generation of monoclonal and polyclonal antibodies for specific projects for the PPG. Dr. Thomas Rosol (Project 4, Co-Pi), who is certified by the American College of Veterinary Pathologist will serve as co-director for the Core. These investigators are joined by experienced technical staff to form a highly experienced professional team to guide the Core and meet the goals of the PPG investigators. A common thread among all research groups is the shared use of unique infectious molecular clones of HTLV-1 and HTLV-2, developed or characterized in our laboratories and links to established animal models to test molecular determinants of disease. Since 2003, the investigators have further evolved multiple new interdependent methods, techniques, and synergistic exchanges that serve to integrate their science to approach basic biological paradigms as desired outcomes from the project laboratories. The highly interactive Animal Core directed by Dr. Niewiesk will provide a central purchasing and procurement method to facilitate animal studies and to reduce redundancy and promote collaborations among the projects. A unique role of the Animal Core will be to provide faculty with expertise in mouse pathology, and provide state-of-the-art methods to determine and quantify bone lesions.