IN-VIVO FUNCTIONAL ONCO-IMAGING (SHARED RESOURCE)

体内功能肿瘤成像(IVFOI)共享资源(SR)的目的是增强和支持 基础和临床癌症研究人员通过为他们提供必要的专业知识、成像 仪器和图像分析技术。本轮筹资周期取得的主要成果有：1) 建立几个多模式成像系统，以支持创新的成像研究；以及2)提供 为转化性临床研究提供高质量的图像采集和数据分析服务。在下一个周期中 我们将继续沿着这些领域发展，以支持调查人员的各种科学需求 赵氏家族综合癌症中心(CFCCC)进行体内成像研究。 目前可用的系统包括三个MRI扫描仪(3T-人、4T-人和动物以及7T-动物)， 以及用于动物和人类的MRI-DOT(漫反射光学断层扫描)联合系统。4T MRI扫描仪为开发新的成像方法提供了一个开放的架构，以及 整合第二种模式，如DOT，形成一个组合系统。一种二维荧光和X射线 目前一些癌症中心成员正在使用的系统将由IVFOI管理。一个3-D原型 建立了与微型CT相结合的荧光生物发光层析成像系统。这些 系统将支持CFCCC成员在设计创新成像组件方面的各种需求 他们的研究，提供解剖学和功能信息。共享资源还将支持 翻译临床研究，具有精确的方案执行和高标准的质量控制。服务请求 一直使用统一的协议支持900多项乳腺MRI研究的收集，因此 已经收集了大量的数据库。在下一个周期中，我们将继续支持此类临床研究，并 还支持使用开发的多模式成像系统的转化型临床研究，例如 评价MRI-DOT联合系统对乳腺癌的诊断性能。 总体而言，IVFOI将为CFCCC成员提供随时获得最先进技术的途径， 为实验和成像方案设计、图像采集和数据分析提供咨询，如 以及各个项目之间的协调。通过共享成像和分析协议，我们将 能够整合从不同项目获得的各种信息，以促进未来的协作 CFCCC成员之间的合作，并将基础科学家和临床研究人员聚集在一起设计和 开展临床翻译研究。

The aim of the In-Vivo Functional Onco-lmaging (IVFOI) Shared Resource (SR) is to enhance and support basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques. The major achievements during this funding cycle are: 1) establishing several multi-modality imaging systems to support innovative imaging studies; and 2) providing high-quality image acquisition and data analysis services for translational clinical studies. In the next cycle we will continue to develop along these areas to support various scientific needs of the investigators at the Chao Family Comprehensive Cancer Center (CFCCC) in performing in-vivo imaging studies. The current available systems include three MRI scanners (3T- human, 4T- human and animal, and 7Tanimal), and a combined MRI-DOT (diffuse optical tomography) system for both animal and human. The 4T MRI scanner provides an open architecture for development of new imaging methods, as well as for integration of the second modality such as DOT to form a combined system. A 2D Fluorescence & X-ray system currently being used by some Cancer Center Members will be managed by IVFOI. A prototype 3-D fluorescence & bioluminescence tomography system integrated with a micro CT has been built. These systems will support various needs of CFCCC Members in designing innovative imaging components into their studies, providing anatomical and functional information. The Shared Resource will also support translational clinical studies, with a precise protocol execution and a high standard quality control. The SR has been supporting the collection of more than 900 breast MRI studies with unified protocols, and as such a large database has been collected. In the next cycle we will continue to support such clinical studies, and also to support translational clinical research using the developed multi-modality imaging system, such as to evaluate the diagnostic performance of the combined MRI-DOT system for breast cancer. Overall, the IVFOI will provide CFCCC Members with ready access to state-of-the-art technologies, consultation for design of experiments and imaging protocols, and image acquisition and data analysis, as well as coordination among individual projects. Through the sharing of imaging and analysis protocol, we will be able to integrate various information obtained from different projects to facilitate future collaboration between CFCCC Members and to bring together basic scientists and clinical researchers to design and conduct clinical translational studies.